TENT4A
Terminal Nucleotidyltransferase 4A
Gene Information Card
| Symbol | TENT4A |
|---|---|
| Full Name | Terminal Nucleotidyltransferase 4A |
| Gene Type | Protein coding |
| Chromosomal Location | 1p33 |
| NCBI Gene ID | 9647 ncbi.nlm.nih.gov/gene/9647 |
| Ensembl ID | ENSG00000117525 |
| UniProt ID | Q5JSL3 |
| OMIM ID | 617133 |
| HGNC ID | 23748 |
| Aliases | Gld4, PAPD7, TUTase4 |
Description
TENT4A (Terminal Nucleotidyltransferase 4A) encodes a non-canonical poly(A) polymerase that adds mixed A and G tails to RNA 3' ends, regulating RNA stability and translation. It is involved in mRNA surveillance and the DNA damage response.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered expression may affect RNA stability of oncogenes/tumor suppressors | COSMIC: mutations found in multiple cancer types |
| Neurodevelopmental disorders | Potential role in RNA processing in neurons | ClinVar: rare variants reported |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 8.5 | Low |
| Liver | 6.1 | Low |
| Kidney | 5.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.4 | Moderate expression |
| HeLa | 9.8 | Moderate expression |
| K562 | 7.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A (p.Gly412Arg) | Missense | 0.01% (gnomAD) | Unknown functional impact |
| c.567_568del (p.Glu189fs) | Frameshift | Rare | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations likely lead to truncated, non-functional protein.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding | • nucleotidyltransferase activity |
| • poly(A) RNA polymerase activity | • cytoplasm |
| • nucleus |
Pathways
• mRNA surveillance pathway
• RNA degradation
Protein Summary
TENT4A is a 729-amino acid protein containing a nucleotidyltransferase domain. It localizes to the cytoplasm and nucleus and functions as a terminal uridylyltransferase, adding uridine tails to RNA, which can promote RNA decay or affect translation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TENT4A Knockout HEK293 Cell Line | EDJ-KQ7259 | Human | 11044 | Details Get a Quote |
| TENT4A Knockout HCT 116 Cell Line | EDJ-KQ30886 | Human | 11044 | Details Get a Quote |
| TENT4A Knockout A-549 Cell Line | EDJ-KQ32268 | Human | 11044 | Details Get a Quote |
| TENT4A Knockout HeLa Cell Line | EDJ-KQ32270 | Human | 11044 | Details Get a Quote |
