TEAD4 Gene: Transcriptional Enhancer Factor TEF-3
Key regulator of Hippo signaling, development, and cancer
Gene Information Card
| Symbol | TEAD4 |
|---|---|
| Full Name | TEA domain transcription factor 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.33 |
| NCBI Gene ID | 7004 ncbi.nlm.nih.gov/gene/7004 |
| Ensembl ID | ENSG00000197905 |
| UniProt ID | Q15561 |
| OMIM ID | 601714 |
| HGNC ID | 11716 |
| Aliases | TEF-3, TCF13L1, RTEF-1 |
Description
TEAD4 encodes a member of the transcriptional enhancer factor (TEF) family, which binds to the MCAT element in muscle-specific genes. It is a key downstream effector of the Hippo signaling pathway, forming complexes with YAP1 and WWTR1 (TAZ) to regulate cell proliferation, differentiation, and organ size. TEAD4 is essential for embryonic development, particularly in trophectoderm specification, and is implicated in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | TEAD4 overexpression promotes YAP1-mediated transcription, driving proliferation and metastasis. | PMID: 25977310 |
| Colorectal cancer | TEAD4 amplification and activation via Hippo pathway mutations enhance tumor growth. | PMID: 24930764 |
| Gastric cancer | TEAD4 upregulation correlates with poor prognosis and activates Wnt/β-catenin signaling. | PMID: 28411376 |
| Hepatocellular carcinoma | TEAD4 overexpression promotes invasion and EMT via YAP1 interaction. | PMID: 26638074 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Skeletal muscle | 10.2 | Medium |
| Placenta | 8.9 | Medium |
| Lung | 6.3 | Low |
| Liver | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.3 | High expression |
| HeLa | 12.1 | Medium expression |
| MCF7 | 9.8 | Medium expression |
| A549 | 7.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Pro34Leu) | Missense | <0.1% | Unknown functional impact |
| c.458G>A (p.Arg153Gln) | Missense | <0.1% | Reported in COSMIC; potential loss of DNA binding |
| c.712C>T (p.Arg238Trp) | Missense | <0.1% | Found in cancer samples; likely gain-of-function |
Mutation functional classification
Loss of Function (LOF)
Mutations disrupting DNA-binding domain (e.g., p.Arg153Gln) reduce transcriptional activity.
Gain of Function (GOF)
Mutations enhancing YAP1 binding or nuclear localization (e.g., p.Arg238Trp) increase oncogenic signaling.
Dominant Negative (DN)
Truncating mutations that interfere with wild-type TEAD4 function are rare.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Hippo signaling pathway (KEGG: hsa04390)
• Transcriptional regulation by the AP-2 family (Reactome: R-HSA-8864260)
• Signaling by Hippo (Reactome: R-HSA-2028269)
Protein Summary
TEAD4 is a 434-amino acid transcription factor containing a TEA/ATTS DNA-binding domain and a C-terminal YAP1-binding domain. It forms a complex with YAP1/TAZ to activate target genes involved in cell growth and survival. Post-translational modifications include phosphorylation and acetylation, which modulate its activity. TEAD4 is widely expressed in adult tissues, with highest levels in heart, skeletal muscle, and placenta.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TEAD4 Knockout HEK293 Cell Line | EDJ-KQ1397 | Human | 7004 | Details Get a Quote |
| TEAD4 Knockout HCT 116 Cell Line | EDJ-KQ20923 | Human | 7004 | Details Get a Quote |
| TEAD4 Knockout HeLa Cell Line | EDJ-KQ20924 | Human | 7004 | Details Get a Quote |
| TEAD4 Knockout A-549 Cell Line | EDJ-KQ19577 | Human | 7004 | Details Get a Quote |
| Tead4 Knockout CT26.WT Cell Line | EDJ-KZ502 | Mouse | 21679 | Details Get a Quote |
Displaying Records 1 To 5 Of 5 Records
