TEAD3 Gene: TEA Domain Transcription Factor 3
Key regulator of Hippo signaling pathway and transcriptional coactivator in development and cancer
Gene Information Card
| Symbol | TEAD3 |
|---|---|
| Full Name | TEA Domain Transcription Factor 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 6p21.31 |
| NCBI Gene ID | 7005 ncbi.nlm.nih.gov/gene/7005 |
| Ensembl ID | ENSG00000112210 |
| UniProt ID | Q99594 |
| OMIM ID | 603170 |
| HGNC ID | 11715 |
| Aliases | DTEF-1, TEAD-3, TEF-5 |
Description
TEAD3 (TEA Domain Transcription Factor 3) is a member of the TEAD family of transcription factors, which share a conserved TEA/ATTS DNA-binding domain. TEAD3 binds to the MCAT element (5'-CATTCCT-3') in the promoters of target genes and acts as a nuclear effector of the Hippo signaling pathway by interacting with YAP1 and WWTR1/TAZ coactivators. It plays critical roles in embryonic development, cell proliferation, and organ size control. TEAD3 is expressed in multiple tissues, including placenta, heart, and skeletal muscle.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | TEAD3 overexpression or aberrant activation via Hippo pathway dysregulation promotes cell proliferation and tumorigenesis | COSMIC, ClinVar |
| Developmental disorders | TEAD3 mutations may disrupt Hippo signaling, affecting organogenesis and growth | OMIM |
| Cardiovascular disease | TEAD3 regulates cardiac gene expression; altered activity linked to heart development defects | NCBI Gene, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Placenta | 12.5 | High |
| Heart | 8.3 | Medium |
| Skeletal muscle | 6.1 | Medium |
| Lung | 4.2 | Low |
| Brain | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | High expression in embryonic kidney cells |
| HeLa | 9.7 | Moderate expression in cervical cancer cells |
| MCF7 | 7.4 | Moderate expression in breast cancer cells |
| A549 | 5.1 | Low expression in lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Pro34Leu) | Missense | Rare | Unknown functional impact; reported in ClinVar |
| c.457G>A (p.Val153Met) | Missense | Rare | Potential loss of DNA binding; limited evidence |
| c.1120_1121insA (p.Thr374Asnfs*5) | Frameshift | Very rare | Predicted loss of function; truncation of C-terminal domain |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the protein, impairing DNA binding or YAP/TAZ interaction, are classified as loss-of-function.
Gain of Function (GOF)
Missense mutations that enhance TEAD3 stability or coactivator binding may act as gain-of-function, but specific examples are not well documented.
Dominant Negative (DN)
Mutations that retain DNA binding but fail to activate transcription could act as dominant-negative, though no confirmed cases are reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Hippo signaling pathway (KEGG: hsa04390)
• Transcriptional regulation by TEAD factors (Reactome: R-HSA-8953854)
• YAP/TAZ coactivator signaling (Reactome: R-HSA-2028269)
Protein Summary
TEAD3 encodes a 435-amino acid protein containing an N-terminal TEA DNA-binding domain and a C-terminal transactivation domain that interacts with YAP1 and WWTR1/TAZ. The protein functions as a transcription factor that regulates genes involved in cell proliferation, differentiation, and organ size control. TEAD3 is ubiquitously expressed with highest levels in placenta, heart, and skeletal muscle. Post-translational modifications include phosphorylation and acetylation, which modulate its activity. TEAD3 is implicated in cancer and developmental disorders through dysregulation of Hippo signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TEAD3 Knockout HEK293 Cell Line | EDJ-KQ947 | Human | 7005 | Details Get a Quote |
| TEAD3 Knockout A-549 Cell Line | EDJ-KQ19933 | Human | 7005 | Details Get a Quote |
| TEAD3 Knockout HCT 116 Cell Line | EDJ-KQ19934 | Human | 7005 | Details Get a Quote |
| TEAD3 Knockout HeLa Cell Line | EDJ-KQ19935 | Human | 7005 | Details Get a Quote |
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