TEAD2
TEA Domain Transcription Factor 2
Gene Information Card
| Symbol | TEAD2 |
|---|---|
| Full Name | TEA domain transcription factor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 8463 ncbi.nlm.nih.gov/gene/8463 |
| Ensembl ID | ENSG00000105568 |
| UniProt ID | Q15562 |
| OMIM ID | 601674 |
| HGNC ID | 11715 |
| Aliases | TEF-4, TEF4, TEAD-2 |
Description
TEAD2 encodes a member of the TEA domain family of transcription factors, which bind to the MCAT element in gene promoters. It is a key downstream effector of the Hippo signaling pathway, regulating cell proliferation, differentiation, and organ size. TEAD2 interacts with YAP1 and WWTR1 (TAZ) to activate target genes involved in development and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Sveinsson chorioretinal atrophy | Dysregulation of TEAD2-mediated transcription; associated with a specific TEAD2 variant | OMIM #108985 |
| Colorectal cancer | TEAD2 overexpression promotes YAP/TAZ-driven proliferation and metastasis | COSMIC, PubMed |
| Hepatocellular carcinoma | TEAD2 amplification and activation of Hippo pathway target genes | COSMIC, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.3 | Medium |
| Skeletal muscle | 9.8 | Medium |
| Placenta | 8.5 | Medium |
| Brain | 6.2 | Low |
| Liver | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.5 | Hepatocellular carcinoma cell line |
| A549 | 8.2 | Lung adenocarcinoma cell line |
| MCF7 | 6.7 | Breast cancer cell line |
| HEK293 | 5.3 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.119C>T (p.Pro40Leu) | Missense | Rare | Alters DNA-binding affinity; associated with Sveinsson chorioretinal atrophy |
| c.457G>A (p.Glu153Lys) | Missense | Rare | Potential loss of function; reported in COSMIC |
| Amplification | Copy number gain | Frequent in cancers | Increases TEAD2 expression; activates Hippo target genes |
Mutation functional classification
Loss of Function (LOF)
Missense variants in the DNA-binding domain (e.g., p.Pro40Leu) reduce transcriptional activity.
Gain of Function (GOF)
Gene amplification or overexpression leads to enhanced YAP/TAZ-mediated transcription.
Dominant Negative (DN)
Not well characterized; some missense variants may interfere with wild-type TEAD2 function.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity | • RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| • Hippo signaling | • cell differentiation |
| • positive regulation of transcription by RNA polymerase II |
Pathways
• Hippo signaling pathway
• Transcriptional regulation by TEAD-YAP/TAZ
Protein Summary
TEAD2 is a 445-amino acid transcription factor containing a TEA DNA-binding domain and a YAP/TAZ-binding domain. It forms complexes with YAP1 or WWTR1 to regulate genes involved in cell growth, apoptosis, and development. Post-translational modifications include phosphorylation and acetylation, modulating its activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TEAD2 Knockout HEK293 Cell Line | EDJ-KQ1398 | Human | 8463 | Details Get a Quote |
| TEAD2 Knockout A-549 Cell Line | EDC08382 | Human | 8463 | Details Get a Quote |
| TEAD2 Knockout HCT 116 Cell Line | EDJ-KQ20926 | Human | 8463 | Details Get a Quote |
| TEAD2 Knockout HeLa Cell Line | EDJ-KQ20927 | Human | 8463 | Details Get a Quote |
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