TCP11L2 Gene
T-Complex 11 Like 2
Gene Information Card
| Symbol | TCP11L2 |
|---|---|
| Full Name | T-Complex 11 Like 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 12q23.3 |
| NCBI Gene ID | 255394 ncbi.nlm.nih.gov/gene/255394 |
| Ensembl ID | ENSG00000174483 |
| UniProt ID | Q8N5H7 |
| OMIM ID | 612241 |
| HGNC ID | 25594 |
| Aliases | FLJ32709, MGC138499, dJ1181N3.1 |
Description
TCP11L2 (T-Complex 11 Like 2) is a protein-coding gene located on chromosome 12q23.3. The encoded protein is predicted to be involved in spermatogenesis and may function in cell differentiation or signaling. Limited functional characterization is available; expression data suggest roles in testis and other tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Medium |
| Brain | 2.1 | Low |
| Lung | 1.8 | Low |
| Liver | 0.9 | Not detected |
| Kidney | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 3.4 | Moderate expression |
| HeLa | 2.0 | Low expression |
| K562 | 1.1 | Low expression |
| HepG2 | 0.8 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Gene Ontology (GO)
| • Molecular function: not yet assigned | • Biological process: spermatogenesis (inferred from sequence similarity) |
| • Cellular component: cytoplasm (inferred) |
Pathways
• No curated pathways
Protein Summary
The TCP11L2 protein is predicted to be a cytoplasmic protein with possible roles in spermatogenesis. Its exact molecular function remains uncharacterized, and no disease associations have been established.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TCP11L2 Knockout HEK293 Cell Line | EDJ-KQ11797 | Human | 255394 | Details Get a Quote |
| TCP11L2 Knockout A-549 Cell Line | EDJ-KQ40212 | Human | 255394 | Details Get a Quote |
| TCP11L2 Knockout HCT 116 Cell Line | EDJ-KQ40213 | Human | 255394 | Details Get a Quote |
| TCP11L2 Knockout HeLa Cell Line | EDJ-KQ40214 | Human | 255394 | Details Get a Quote |
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