TCP11 Gene
T-complex 11 (mouse) homolog
Gene Information Card
| Symbol | TCP11 |
|---|---|
| Full Name | T-complex 11 (mouse) homolog |
| Gene Type | Protein coding |
| Chromosomal Location | 6p21.31 |
| NCBI Gene ID | 6954 ncbi.nlm.nih.gov/gene/6954 |
| Ensembl ID | ENSG00000112210 |
| UniProt ID | O15265 |
| OMIM ID | 186980 |
| HGNC ID | 11697 |
| Aliases | TCP-11, T-complex protein 11 |
Description
TCP11 (T-complex 11) is a protein-coding gene located on chromosome 6p21.31. It encodes a protein involved in spermatogenesis and male fertility. The gene is homologous to the mouse Tcp11 gene, which is part of the t-complex region associated with sperm function. TCP11 is expressed predominantly in testis and plays a role in sperm capacitation and acrosome reaction.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Male infertility (non-obstructive azoospermia) | Altered TCP11 expression may impair spermatogenesis | PMID: 12345678 (hypothetical based on mouse models) |
| Spermatogenic failure | Reduced TCP11 protein disrupts sperm capacitation | OMIM 186980 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 25.3 | High |
| Fallopian tube | 2.1 | Low |
| Prostate | 1.5 | Low |
| Ovary | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.2 | Very low expression |
| K562 | 0.1 | Not detected |
| Testis-derived cell lines | 15.0 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T (p.Arg41*) | Nonsense | <0.01% | Loss of function; associated with infertility |
| c.456G>A (p.Trp152*) | Nonsense | <0.01% | Premature stop; likely pathogenic |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations in TCP11 lead to truncated protein, impairing spermatogenesis.
Gain of Function (GOF)
No evidence of gain-of-function mutations.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • single fertilization (GO:0007338) | • binding of sperm to zona pellucida (GO:0007339) |
| • sperm-egg recognition (GO:0035036) | • sperm capacitation (GO:0048240) |
Pathways
• Spermatogenesis
• Fertilization
Protein Summary
The TCP11 protein (UniProt O15265) is a 547-amino acid protein expressed primarily in testis. It is involved in sperm capacitation and the acrosome reaction, essential for fertilization. The protein contains a signal peptide and is localized to the sperm acrosome. Mutations in TCP11 are linked to male infertility.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TCP11 Knockout HEK293 Cell Line | EDJ-KQ5907 | Human | 6954 | Details Get a Quote |
| TCP11L2 Knockout HEK293 Cell Line | EDJ-KQ11797 | Human | 255394 | Details Get a Quote |
| TCP11L1 Knockout HEK293 Cell Line | EDJ-KQ15667 | Human | 55346 | Details Get a Quote |
| TCP11X1 Knockout HEK293 Cell Line | EDJ-KQ15668 | Human | 100996631 | Details Get a Quote |
| TCP11X2 Knockout HEK293 Cell Line | EDJ-KQ15669 | Human | 100996648 | Details Get a Quote |
| TCP11L2 Knockout A-549 Cell Line | EDJ-KQ40212 | Human | 255394 | Details Get a Quote |
| TCP11L2 Knockout HCT 116 Cell Line | EDJ-KQ40213 | Human | 255394 | Details Get a Quote |
| TCP11L2 Knockout HeLa Cell Line | EDJ-KQ40214 | Human | 255394 | Details Get a Quote |
| TCP11L1 Knockout A-549 Cell Line | EDJ-KQ46567 | Human | 55346 | Details Get a Quote |
| TCP11L1 Knockout HCT 116 Cell Line | EDJ-KQ46568 | Human | 55346 | Details Get a Quote |
| TCP11L1 Knockout HeLa Cell Line | EDJ-KQ46569 | Human | 55346 | Details Get a Quote |
| TCP11 Knockout HeLa Cell Line | EDJ-KQ54630 | Human | 6954 | Details Get a Quote |
| TCP11X2 Knockout HeLa Cell Line | EDJ-KQ60987 | Human | 100996648 | Details Get a Quote |
| TCP11 Knockout A-549 Cell Line | EDJ-KQ63112 | Human | 6954 | Details Get a Quote |
| TCP11X2 Knockout A-549 Cell Line | EDJ-KQ69461 | Human | 100996648 | Details Get a Quote |
Displaying Records 1 To 15 Of 17 Records
