TCL1B
TCL1 Family B, Coactivator of AKT Kinase
Gene Information Card
| Symbol | TCL1B |
|---|---|
| Full Name | TCL1 family B |
| Gene Type | protein-coding |
| Chromosomal Location | 14q32.13 |
| NCBI Gene ID | 9623 ncbi.nlm.nih.gov/gene/9623 |
| Ensembl ID | ENSG00000100811 |
| UniProt ID | O95988 |
| OMIM ID | 601769 |
| HGNC ID | 11619 |
| Aliases | TCL1/MTCP1-like, TCL1L |
Description
TCL1B (TCL1 family B) is a protein-coding gene located on chromosome 14q32.13. It belongs to the TCL1 family, which also includes TCL1A and MTCP1. The encoded protein functions as a coactivator of the AKT serine/threonine kinase, enhancing AKT-mediated signaling pathways. TCL1B is predominantly expressed in lymphoid tissues and is implicated in the pathogenesis of T-cell prolymphocytic leukemia (T-PLL) through chromosomal rearrangements that lead to its overexpression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| T-cell prolymphocytic leukemia (T-PLL) | Overexpression of TCL1B due to t(14;14)(q32;q13) or inv(14)(q32q13) activates AKT signaling, promoting T-cell survival and proliferation. | PMID: 10591208, OMIM 601769 |
| B-cell chronic lymphocytic leukemia (B-CLL) | Rare rearrangements involving TCL1B may contribute to leukemogenesis via AKT pathway activation. | PMID: 10591208 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Bone marrow | 8.1 | Low |
| Thymus | 6.7 | Low |
| Peripheral blood leukocytes | 5.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Jurkat (T-cell leukemia) | 15.0 | High expression |
| Raji (Burkitt lymphoma) | 9.8 | Moderate expression |
| K562 (chronic myeloid leukemia) | 2.1 | Low expression |
| HEK293 (embryonic kidney) | 0.5 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1Val) | Missense | <0.1% | Likely loss of start codon; functional impact unknown |
| c.200C>T (p.Pro67Leu) | Missense | <0.1% | Rare variant; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in TCL1B.
Gain of Function (GOF)
Overexpression due to chromosomal rearrangements (e.g., t(14;14)) is considered a gain-of-function mechanism in T-PLL.
Dominant Negative (DN)
No dominant-negative mutations described for TCL1B.
View complete mutation data：
Gene Ontology (GO)
| • p53 binding (GO:0002039) | • identical protein binding (GO:0042802) |
| • metal ion binding (GO:0046872) | • cytoplasm (GO:0005737) |
| • nucleus (GO:0005634) |
Pathways
• PI3K-Akt signaling pathway (Reactome: R-HSA-1257604)
• AKT phosphorylates targets in the cytosol (Reactome: R-HSA-198203)
Protein Summary
The TCL1B protein (UniProt O95988) is a 128-amino acid polypeptide that shares structural homology with TCL1A. It contains a TCL1 domain and functions as a coactivator of AKT by binding to the pleckstrin homology (PH) domain of AKT, enhancing its kinase activity. The protein is predominantly cytoplasmic and nuclear in lymphoid cells. Overexpression of TCL1B in T-cell malignancies promotes AKT-dependent survival signals.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TCL1B Knockout HEK293 Cell Line | EDJ-KQ871 | Human | 9623 | Details Get a Quote |
| TCL1B Knockout HeLa Cell Line | EDJ-KQ55208 | Human | 9623 | Details Get a Quote |
| TCL1B Knockout A-549 Cell Line | EDJ-KQ63690 | Human | 9623 | Details Get a Quote |
| TCL1B Knockout HCT 116 Cell Line | EDJ-KQ72153 | Human | 9623 | Details Get a Quote |
