TCF25: Transcription Factor 25 and Its Role in Cellular Processes
A comprehensive overview of TCF25, including gene characteristics, expression, mutations, and associated diseases.
Gene Information Card
| Symbol | TCF25 |
|---|---|
| Full Name | Transcription Factor 25 |
| Gene Type | Protein coding |
| Chromosomal Location | 16q24.3 |
| NCBI Gene ID | 22980 ncbi.nlm.nih.gov/gene/22980 |
| Ensembl ID | ENSG00000141002 |
| UniProt ID | Q9BQ70 |
| OMIM ID | 617533 |
| HGNC ID | 29181 |
| Aliases | FKSG24, NULP1, bA99L14.2 |
Description
TCF25 (Transcription Factor 25) is a protein-coding gene located on chromosome 16q24.3. It encodes a basic helix-loop-helix (bHLH) transcription factor involved in the regulation of gene expression, cell proliferation, and differentiation. TCF25 is also known as NULP1 (Nuclear Ubiquitous Late-binding Protein 1) and FKSG24. It interacts with other transcription factors and may play a role in development and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | TCF25 overexpression may promote tumor growth via transcriptional regulation of target genes. | COSMIC; PMID: 25691885 |
| Lung Cancer | Altered TCF25 expression linked to poor prognosis; potential oncogenic role. | COSMIC; PMID: 27197149 |
| Breast Cancer | TCF25 expression changes observed in tumor samples; mechanism unclear. | COSMIC; PMID: 29056339 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lung | 8.3 | Low |
| Colon | 6.7 | Low |
| Breast | 5.1 | Low |
| Brain | 2.4 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| A549 | 9.8 | Lung cancer cell line |
| MCF7 | 7.3 | Breast cancer cell line |
| HCT116 | 11.4 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | 0.02% | Unknown; may affect DNA binding |
| c.1246G>A (p.Gly416Ser) | Missense | 0.01% | Unknown; possibly benign |
| c.1450_1451insA | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.1450_1451insA) likely result in truncated, non-functional protein.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • GO:0000978 (GO:0000978) | • GO:0000981 (GO:0000981) |
| • GO:0001227 (GO:0001227) | • GO:0005634 (GO:0005634) |
| • GO:0006357 (GO:0006357) | • GO:0045944 (GO:0045944) |
Pathways
• Notch signaling pathway (Reactome: R-HSA-157118)
• Transcriptional regulation by bHLH factors (KEGG: hsa04330)
Protein Summary
TCF25 encodes a 667-amino acid protein containing a basic helix-loop-helix (bHLH) domain, which mediates DNA binding and dimerization. The protein localizes to the nucleus and acts as a transcription factor, regulating genes involved in cell cycle and differentiation. It interacts with proteins such as TCF3 and may modulate Notch signaling. Expression is highest in testis, with lower levels in lung, colon, and breast tissues. Mutations are rare but may contribute to cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TCF25 Knockout HEK293 Cell Line | EDJ-KQ7762 | Human | 22980 | Details Get a Quote |
| TCF25 Knockout A-549 Cell Line | EDJ-KQ33218 | Human | 22980 | Details Get a Quote |
| TCF25 Knockout HCT 116 Cell Line | EDJ-KQ33219 | Human | 22980 | Details Get a Quote |
| TCF25 Knockout HeLa Cell Line | EDJ-KQ33220 | Human | 22980 | Details Get a Quote |
