TCERG1L
Transcription Elongation Regulator 1 Like
Gene Information Card
| Symbol | TCERG1L |
|---|---|
| Full Name | Transcription Elongation Regulator 1 Like |
| Gene Type | protein-coding |
| Chromosomal Location | 10q26.3 |
| NCBI Gene ID | 256329 ncbi.nlm.nih.gov/gene/256329 |
| Ensembl ID | ENSG00000120068 |
| UniProt ID | Q5VWG9 |
| OMIM ID | 617447 |
| HGNC ID | 28333 |
| Aliases | FLJ38973, MGC35130, C10orf79 |
Description
TCERG1L (Transcription Elongation Regulator 1 Like) is a protein-coding gene located on chromosome 10q26.3. It encodes a protein that shares homology with TCERG1, which is involved in transcription elongation and pre-mRNA splicing. The precise function of TCERG1L is not fully characterized, but it is predicted to play a role in transcriptional regulation. Expression data suggest broad tissue distribution with highest levels in testis and brain.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 8.2 | Medium |
| Brain | 5.1 | Low |
| Lung | 2.3 | Low |
| Liver | 1.0 | Not detected |
| Kidney | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 3.4 | Low expression |
| HeLa | 2.1 | Low expression |
| K562 | 1.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Protein Summary
The TCERG1L protein (UniProt Q5VWG9) is a 1,074-amino-acid polypeptide with a predicted molecular weight of ~120 kDa. It contains a WW domain and multiple PEST motifs, suggesting involvement in protein-protein interactions and rapid turnover. No experimental structure is available; function remains inferred from homology to TCERG1.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TCERG1L Knockout HEK293 Cell Line | EDJ-KQ11836 | Human | 256536 | Details Get a Quote |
| TCERG1L Knockout HeLa Cell Line | EDJ-KQ59306 | Human | 256536 | Details Get a Quote |
| TCERG1L Knockout A-549 Cell Line | EDJ-KQ67773 | Human | 256536 | Details Get a Quote |
| TCERG1L Knockout HCT 116 Cell Line | EDJ-KQ76155 | Human | 256536 | Details Get a Quote |
