TCEANC2
Transcription Elongation Factor A N-Terminal and Central Domain Containing 2
Gene Information Card
| Symbol | TCEANC2 |
|---|---|
| Full Name | Transcription Elongation Factor A N-Terminal and Central Domain Containing 2 |
| Gene Type | Protein-coding |
| Chromosomal Location | 1p36.33 |
| NCBI Gene ID | 127253 ncbi.nlm.nih.gov/gene/127253 |
| Ensembl ID | ENSG00000142611 |
| UniProt ID | Q6P2H3 |
| OMIM ID | 617157 |
| HGNC ID | 28700 |
| Aliases | FLJ32743, TCEA2L, TCEA-NC2 |
Description
TCEANC2 encodes a protein that contains an N-terminal and central domain similar to transcription elongation factor A (TCEA). The protein is predicted to be involved in transcription elongation regulation, though its specific biological role is not fully characterized. The gene is located on chromosome 1p36.33 and is expressed in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease association reported in ClinVar or OMIM | Not applicable | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Brain | 3.1 | Low |
| Lung | 2.8 | Low |
| Liver | 1.5 | Not detected |
| Heart | 2.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 4.5 | Moderate expression |
| HeLa | 3.0 | Low expression |
| K562 | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • transcription, DNA-templated (GO:0006351) | • nucleus (GO:0005634) |
Pathways
• No curated pathways available
Protein Summary
The TCEANC2 protein is 244 amino acids long and contains a TCEA-like N-terminal domain and a central domain. It is predicted to localize to the nucleus and may participate in transcription elongation. Its exact function remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TCEANC2 Knockout HEK293 Cell Line | EDJ-KQ9041 | Human | 127428 | Details Get a Quote |
| TCEANC2 Knockout HCT 116 Cell Line | EDJ-KQ34236 | Human | 127428 | Details Get a Quote |
| TCEANC2 Knockout A-549 Cell Line | EDJ-KQ35486 | Human | 127428 | Details Get a Quote |
| TCEANC2 Knockout HeLa Cell Line | EDJ-KQ35487 | Human | 127428 | Details Get a Quote |
