TCEAL4
Transcription Elongation Factor A Like 4
Gene Information Card
| Symbol | TCEAL4 |
|---|---|
| Full Name | Transcription Elongation Factor A Like 4 |
| Gene Type | Protein coding |
| Chromosomal Location | Xq22.2 |
| NCBI Gene ID | 79921 ncbi.nlm.nih.gov/gene/79921 |
| Ensembl ID | ENSG00000147133 |
| UniProt ID | Q96EI5 |
| OMIM ID | 300627 |
| HGNC ID | 11619 |
| Aliases | WEX4, TCEAL4 |
Description
TCEAL4 (Transcription Elongation Factor A Like 4) is a protein-coding gene located on the X chromosome. It belongs to the TCEAL family, which encodes proteins that modulate transcription elongation by interacting with RNA polymerase II. TCEAL4 is widely expressed in various tissues and has been implicated in cancer and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of transcription elongation; altered expression in tumors | COSMIC, NCBI Gene |
| X-linked intellectual disability | Potential role in neuronal transcription regulation | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Testis | 15.2 | Medium |
| Heart | 9.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.0 | Embryonic kidney |
| HeLa | 11.2 | Cervical cancer |
| A549 | 9.5 | Lung cancer |
| K562 | 7.8 | Leukemia |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | Rare | Unknown functional impact |
| c.100C>T | Nonsense | Rare | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations may lead to truncated protein and loss of function.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • transcription elongation factor activity | • nucleus |
| • RNA polymerase II binding |
Pathways
• Transcription elongation by RNA polymerase II
Protein Summary
TCEAL4 encodes a 227-amino acid protein that localizes to the nucleus and interacts with RNA polymerase II to regulate transcription elongation. It is part of the TCEAL family, which shares a conserved N-terminal domain. The protein is expressed in multiple tissues and may play a role in cell proliferation and differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TCEAL4 Knockout HEK293 Cell Line | EDJ-KQ15659 | Human | 79921 | Details Get a Quote |
| TCEAL4 Knockout HeLa Cell Line | EDJ-KQ45330 | Human | 79921 | Details Get a Quote |
| TCEAL4 Knockout A-549 Cell Line | EDJ-KQ46561 | Human | 79921 | Details Get a Quote |
| TCEAL4 Knockout HCT 116 Cell Line | EDJ-KQ46562 | Human | 79921 | Details Get a Quote |
