TCEA3
Transcription Elongation Factor A3
Gene Information Card
| Symbol | TCEA3 |
|---|---|
| Full Name | Transcription Elongation Factor A3 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p36.12 |
| NCBI Gene ID | 9330 ncbi.nlm.nih.gov/gene/9330 |
| Ensembl ID | ENSG00000117525 |
| UniProt ID | Q15717 |
| OMIM ID | 604784 |
| HGNC ID | 11616 |
| Aliases | TFIIS, TCEA3, SII, TCEA3_HUMAN |
Description
TCEA3 encodes a member of the transcription elongation factor A (SII) family. This protein is an RNA polymerase II elongation factor that facilitates transcriptional read-through by reactivating arrested RNA polymerase II complexes. It is involved in regulating gene expression during development and in response to cellular stress. TCEA3 is expressed in multiple tissues and has been implicated in cancer and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered TCEA3 expression may affect transcriptional elongation of tumor suppressor or oncogenes, contributing to tumorigenesis. | COSMIC; literature |
| Developmental disorders | Mutations in TCEA3 may disrupt transcriptional regulation during embryogenesis. | OMIM; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 8.5 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.0 | Moderate expression |
| HeLa | 9.5 | Moderate expression |
| A549 | 7.8 | Low expression |
| K562 | 6.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Ile) | Missense | <0.01% | Unknown functional impact |
| c.205G>A (p.Gly69Ser) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; some missense variants may reduce elongation activity.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • RNA polymerase II transcription elongation factor activity | • transcription elongation from RNA polymerase II promoter |
| • nucleus | • protein binding |
Pathways
• RNA polymerase II transcription elongation
• Transcription-coupled nucleotide excision repair
Protein Summary
TCEA3 is a 301-amino acid protein that contains a conserved SII-type zinc finger domain and a TFIIS central domain. It binds to RNA polymerase II and stimulates its ability to read through transcriptional pause sites. The protein is localized to the nucleus and is expressed in a variety of tissues, with highest levels in testis. TCEA3 plays a role in maintaining genomic stability by facilitating transcription elongation and may be involved in DNA repair processes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TCEA3 Knockout HEK293 Cell Line | EDJ-KQ5892 | Human | 6920 | Details Get a Quote |
| TCEA3 Knockout HCT 116 Cell Line | EDJ-KQ29392 | Human | 6920 | Details Get a Quote |
| TCEA3 Knockout HeLa Cell Line | EDJ-KQ29393 | Human | 6920 | Details Get a Quote |
| TCEA3 Knockout A-549 Cell Line | EDJ-KQ63103 | Human | 6920 | Details Get a Quote |
