TCEA2
Transcription Elongation Factor A2
Gene Information Card
| Symbol | TCEA2 |
|---|---|
| Full Name | Transcription Elongation Factor A2 |
| Gene Type | protein-coding |
| Chromosomal Location | 20q13.33 |
| NCBI Gene ID | 6919 ncbi.nlm.nih.gov/gene/6919 |
| Ensembl ID | ENSG00000101203 |
| UniProt ID | P23193 |
| OMIM ID | 602691 |
| HGNC ID | 11617 |
| Aliases | TFIIS, TCEA, SII |
Description
TCEA2 encodes a member of the transcription elongation factor A (SII) family. This protein is an RNA polymerase II elongation factor that facilitates transcription by reactivating arrested RNA polymerase II complexes. It is ubiquitously expressed and plays a role in transcriptional regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | Not applicable |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 5.3 | Low |
| Kidney | 7.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | High expression |
| HeLa | 12.3 | Medium expression |
| K562 | 9.8 | Medium expression |
| A549 | 7.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Likely loss of function |
| c.100C>T (p.Arg34Trp) | missense | <0.01% | Unknown significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• RNA polymerase II transcription elongation (Reactome: R-HSA-75955)
Protein Summary
TCEA2 is a 299-amino acid protein that contains a zinc ribbon domain and a TFIIS-type domain. It binds to RNA polymerase II and stimulates transcription elongation by promoting readthrough of pause sites. The protein is localized to the nucleus and is expressed in many tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TCEA2 Knockout HEK293 Cell Line | EDJ-KQ5891 | Human | 6919 | Details Get a Quote |
| TCEA2 Knockout A-549 Cell Line | EDJ-KQ28121 | Human | 6919 | Details Get a Quote |
| TCEA2 Knockout HCT 116 Cell Line | EDJ-KQ29390 | Human | 6919 | Details Get a Quote |
| TCEA2 Knockout HeLa Cell Line | EDJ-KQ29391 | Human | 6919 | Details Get a Quote |
