TATDN3
TatD DNase Domain Containing 3
Gene Information Card
| Symbol | TATDN3 |
|---|---|
| Full Name | TatD DNase Domain Containing 3 |
| Gene Type | Protein-coding |
| Chromosomal Location | 1q32.1 |
| NCBI Gene ID | 126321 ncbi.nlm.nih.gov/gene/126321 |
| Ensembl ID | ENSG00000143149 |
| UniProt ID | Q6P1N9 |
| OMIM ID | 617058 |
| HGNC ID | 28323 |
| Aliases | FLJ22624, MGC131891 |
Description
TATDN3 (TatD DNase Domain Containing 3) is a protein-coding gene located on chromosome 1q32.1. The encoded protein contains a TatD DNase domain, which is conserved across species and is implicated in DNA repair and apoptosis. TATDN3 is expressed in multiple tissues and may play a role in cellular stress responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 8.5 | Low |
| Liver | 6.1 | Low |
| Kidney | 5.3 | Low |
| Heart | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.3 | Embryonic kidney cells |
| HeLa | 9.8 | Cervical cancer cells |
| K562 | 7.1 | Leukemia cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • DNA binding | • DNase activity |
| • nucleus | • cytoplasm |
| • apoptotic process |
Pathways
• No specific pathways curated
Protein Summary
The TATDN3 protein (UniProt Q6P1N9) is 363 amino acids long and contains a TatD DNase domain. It is predicted to have deoxyribonuclease activity and may be involved in DNA degradation during apoptosis. Subcellular localization is nuclear and cytoplasmic.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TATDN3 Knockout HEK293 Cell Line | EDJ-KQ9170 | Human | 128387 | Details Get a Quote |
| TATDN3 Knockout A-549 Cell Line | EDJ-KQ35711 | Human | 128387 | Details Get a Quote |
| TATDN3 Knockout HCT 116 Cell Line | EDJ-KQ35712 | Human | 128387 | Details Get a Quote |
| TATDN3 Knockout HeLa Cell Line | EDJ-KQ35713 | Human | 128387 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
