TAS2R9: Bitter Taste Receptor Family Member 9
A member of the TAS2R family of G protein-coupled receptors involved in bitter taste perception.
Gene Information Card
| Symbol | TAS2R9 |
|---|---|
| Full Name | Taste 2 Receptor Member 9 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 50835 ncbi.nlm.nih.gov/gene/50835 |
| Ensembl ID | ENSG00000121318 |
| UniProt ID | Q9NYW0 |
| OMIM ID | 604796 |
| HGNC ID | 14918 |
| Aliases | T2R9, TAS2R9, taste receptor type 2 member 9 |
Description
TAS2R9 encodes a member of the TAS2R family of bitter taste receptors, which are G protein-coupled receptors (GPCRs) expressed primarily in taste receptor cells of the tongue and palate. These receptors mediate the perception of bitter compounds, playing a role in detecting potentially toxic substances. TAS2R9 is also expressed in extraoral tissues, suggesting additional physiological functions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception variation | Polymorphisms in TAS2R9 alter receptor sensitivity to specific bitter compounds, contributing to individual differences in taste perception. | Association studies (PMID: 15817855) |
| Upper aerodigestive tract cancers | Extraoral expression of TAS2R9 in respiratory and gastrointestinal tissues may influence chemosensory responses linked to cancer risk. | Limited evidence from expression profiling (PMID: 23201722) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue | 0.0 | Not detected (nTPM < 1) |
| Salivary gland | 0.0 | Not detected |
| Esophagus | 0.0 | Not detected |
| Stomach | 0.0 | Not detected |
| Small intestine | 0.0 | Not detected |
| Colon | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
| Lung | 0.0 | Not detected |
| Thyroid | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.0 | No detectable expression in standard RNA-seq |
| HeLa | 0.0 | No detectable expression |
| K562 | 0.0 | No detectable expression |
| MCF7 | 0.0 | No detectable expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs3741845 (c.145C>T) | SNP | 0.15 (global) | Missense (p.Pro49Ser); may alter receptor function |
| rs1204014 (c.316G>A) | SNP | 0.22 (global) | Missense (p.Val106Ile); potential effect on ligand binding |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in TAS2R9.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
Not applicable; TAS2R9 functions as a monomeric GPCR.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Taste transduction (KEGG: hsa04742)
• GPCR downstream signaling (Reactome: R-HSA-372790)
Protein Summary
TAS2R9 is a 299-amino acid integral membrane protein with seven transmembrane domains, characteristic of GPCRs. It is expressed in taste buds and extraoral tissues, where it binds bitter compounds and activates gustducin-mediated signaling cascades. Structural variations in the ligand-binding pocket contribute to inter-individual differences in bitter taste sensitivity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R9 Knockout HEK293 Cell Line | EDJ-KQ10823 | Human | 50835 | Details Get a Quote |
| TAS2R9 Knockout HeLa Cell Line | EDJ-KQ56192 | Human | 50835 | Details Get a Quote |
| TAS2R9 Knockout A-549 Cell Line | EDJ-KQ64681 | Human | 50835 | Details Get a Quote |
| TAS2R9 Knockout HCT 116 Cell Line | EDJ-KQ73129 | Human | 50835 | Details Get a Quote |
