TAS2R8
Taste 2 Receptor Member 8
Gene Information Card
| Symbol | TAS2R8 |
|---|---|
| Full Name | Taste 2 Receptor Member 8 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 50836 ncbi.nlm.nih.gov/gene/50836 |
| Ensembl ID | ENSG00000127399 |
| UniProt ID | Q9NYW0 |
| OMIM ID | 604796 |
| HGNC ID | 14915 |
| Aliases | T2R8, TRB5 |
Description
TAS2R8 encodes a member of the TAS2R family of bitter taste receptors, which are G protein-coupled receptors (GPCRs) expressed primarily in taste receptor cells of the tongue and palate. These receptors mediate the perception of bitter compounds, playing a role in detecting potentially toxic substances in food.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No curated disease entries in OMIM or ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue | 0.0 | Not detected |
| Salivary gland | 0.0 | Not detected |
| Esophagus | 0.0 | Not detected |
| Stomach | 0.0 | Not detected |
| Small intestine | 0.0 | Not detected |
| Colon | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
| Pancreas | 0.0 | Not detected |
| Kidney | 0.0 | Not detected |
| Lung | 0.0 | Not detected |
| Heart | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
| Ovary | 0.0 | Not detected |
| Prostate | 0.0 | Not detected |
| Breast | 0.0 | Not detected |
| Skin | 0.0 | Not detected |
| Adipose tissue | 0.0 | Not detected |
| Thyroid | 0.0 | Not detected |
| Adrenal gland | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No data available |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants in COSMIC or ClinVar |
Mutation functional classification
Loss of Function (LOF)
No functional data available
Gain of Function (GOF)
No functional data available
Dominant Negative (DN)
No functional data available
View complete mutation data：
Gene Ontology (GO)
Pathways
• ['Sensory perception of bitter taste (Reactome: R-HSA-975110)']
Protein Summary
TAS2R8 is a 317-amino acid protein belonging to the TAS2R family of bitter taste receptors. It is a GPCR with seven transmembrane domains, localized to the plasma membrane of taste receptor cells. The receptor binds bitter compounds and activates downstream signaling via gustducin, leading to perception of bitterness.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R8 Knockout HEK293 Cell Line | EDJ-KQ10824 | Human | 50836 | Details Get a Quote |
| TAS2R8 Knockout HeLa Cell Line | EDJ-KQ56193 | Human | 50836 | Details Get a Quote |
| TAS2R8 Knockout A-549 Cell Line | EDJ-KQ64682 | Human | 50836 | Details Get a Quote |
| TAS2R8 Knockout HCT 116 Cell Line | EDJ-KQ73130 | Human | 50836 | Details Get a Quote |
