TAS2R7: Taste 2 Receptor Member 7
Bitter taste receptor gene involved in sensory perception of bitter compounds
Gene Information Card
| Symbol | TAS2R7 |
|---|---|
| Full Name | Taste 2 Receptor Member 7 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 50837 ncbi.nlm.nih.gov/gene/50837 |
| Ensembl ID | ENSG00000127399 |
| UniProt ID | Q9NYW0 |
| OMIM ID | 604793 |
| HGNC ID | 14912 |
| Aliases | T2R7, TRB7 |
Description
TAS2R7 encodes a member of the TAS2R family of bitter taste receptors, which are G protein-coupled receptors (GPCRs) expressed primarily in taste receptor cells of the tongue and palate. This receptor mediates the perception of bitterness in response to various natural and synthetic bitter compounds. TAS2R7 is also expressed in extraoral tissues, suggesting roles beyond taste, such as in chemosensation in the respiratory and gastrointestinal tracts.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease association reported in ClinVar or OMIM | Not applicable | No curated evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue | 0.0 | Not detected |
| Salivary gland | 0.0 | Not detected |
| Esophagus | 0.0 | Not detected |
| Stomach | 0.0 | Not detected |
| Small intestine | 0.0 | Not detected |
| Colon | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
| Pancreas | 0.0 | Not detected |
| Kidney | 0.0 | Not detected |
| Lung | 0.0 | Not detected |
| Heart | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
| Ovary | 0.0 | Not detected |
| Prostate | 0.0 | Not detected |
| Breast | 0.0 | Not detected |
| Skin | 0.0 | Not detected |
| Adipose tissue | 0.0 | Not detected |
| Thyroid | 0.0 | Not detected |
| Adrenal gland | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No data available | N/A | No expression data in cell lines from GTEx or HPA |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No functional studies available
Gain of Function (GOF)
No functional studies available
Dominant Negative (DN)
No functional studies available
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • bitter taste receptor activity |
| • detection of chemical stimulus involved in sensory perception of bitter taste | • plasma membrane |
| • signal transduction |
Pathways
• Taste transduction (KEGG: hsa04742)
Protein Summary
TAS2R7 is a 299-amino acid integral membrane protein belonging to the TAS2R family of bitter taste receptors. It contains seven transmembrane domains characteristic of GPCRs. The protein is activated by bitter compounds such as denatonium and quinine, leading to intracellular signaling via gustducin and downstream calcium mobilization. Structural polymorphisms may influence individual differences in bitter taste sensitivity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R7 Knockout HEK293 Cell Line | EDJ-KQ10103 | Human | 50837 | Details Get a Quote |
| TAS2R7 Knockout HeLa Cell Line | EDJ-KQ56194 | Human | 50837 | Details Get a Quote |
| TAS2R7 Knockout A-549 Cell Line | EDJ-KQ64683 | Human | 50837 | Details Get a Quote |
| TAS2R7 Knockout HCT 116 Cell Line | EDJ-KQ73131 | Human | 50837 | Details Get a Quote |
