TAS2R60
Taste 2 Receptor Member 60
Gene Information Card
| Symbol | TAS2R60 |
|---|---|
| Full Name | Taste 2 Receptor Member 60 |
| Gene Type | protein-coding |
| Chromosomal Location | 7q34 |
| NCBI Gene ID | 338398 ncbi.nlm.nih.gov/gene/338398 |
| Ensembl ID | ENSG00000212318 |
| UniProt ID | P59543 |
| OMIM ID | 613966 |
| HGNC ID | 18889 |
| Aliases | T2R60, TAS2R60P, hT2R60 |
Description
TAS2R60 (Taste 2 Receptor Member 60) is a protein-coding gene that belongs to the TAS2R family of bitter taste receptors. These receptors are G protein-coupled receptors (GPCRs) expressed primarily in taste receptor cells of the tongue and palate, where they mediate the perception of bitter compounds. TAS2R60 is located on chromosome 7q34 and encodes a 299-amino acid protein. The gene is intronless and is considered a functional bitter taste receptor, though its specific ligands are not fully characterized.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception (polymorphism-related) | Variants in TAS2R60 may alter receptor sensitivity to bitter compounds, influencing dietary preferences and potential associations with food intake behaviors. | Limited; inferred from family studies and population genetics (NCBI, ClinVar) |
| No direct disease association established | No known pathogenic mutations in TAS2R60 have been linked to Mendelian disorders. | No evidence in OMIM or ClinVar as of current data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue (taste buds) | Not quantified (nTPM not available) | High (specific expression) |
| Testis | 0.3 | Low |
| Esophagus | 0.1 | Low |
| Other tissues | <0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Taste receptor cells (primary) | Not applicable | Endogenous expression |
| HEK293 (heterologous) | Not applicable | Used for functional assays |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs61735836 (p.Arg299Cys) | missense | 0.2% (gnomAD) | Unknown; may alter receptor function |
| rs150815484 (p.Leu100Phe) | missense | 0.1% (gnomAD) | Unknown; predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in TAS2R60.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • bitter taste receptor activity (GO:0033038) |
| • taste transduction (GO:0050913) | • plasma membrane (GO:0005886) |
Pathways
• Taste transduction (KEGG: hsa04742)
Protein Summary
TAS2R60 is a 299-amino acid integral membrane protein with seven transmembrane domains, characteristic of G protein-coupled receptors. It is expressed on the surface of taste receptor cells and activates intracellular signaling via gustducin (GNAT3) upon binding bitter compounds. The protein is encoded by an intronless gene and shares sequence homology with other TAS2R family members. Structural studies are limited, but homology models suggest a typical GPCR fold with a ligand-binding pocket in the transmembrane region.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R60 Knockout HEK293 Cell Line | EDJ-KQ15627 | Human | 338398 | Details Get a Quote |
| TAS2R60 Knockout HeLa Cell Line | EDJ-KQ59610 | Human | 338398 | Details Get a Quote |
| TAS2R60 Knockout A-549 Cell Line | EDJ-KQ68075 | Human | 338398 | Details Get a Quote |
| TAS2R60 Knockout HCT 116 Cell Line | EDJ-KQ76452 | Human | 338398 | Details Get a Quote |
