TAS2R50
Taste 2 Receptor Member 50
Gene Information Card
| Symbol | TAS2R50 |
|---|---|
| Full Name | Taste 2 Receptor Member 50 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 259296 ncbi.nlm.nih.gov/gene/259296 |
| Ensembl ID | ENSG00000212127 |
| UniProt ID | P59543 |
| OMIM ID | 613967 |
| HGNC ID | 18811 |
| Aliases | T2R50, TAS2R50, taste receptor type 2 member 50 |
Description
TAS2R50 encodes a member of the taste receptor type 2 (T2R) family of G protein-coupled receptors. These receptors are primarily expressed in taste receptor cells of the tongue and palate and mediate bitter taste perception. TAS2R50 is a functional bitter taste receptor that responds to various bitter compounds.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception (normal variation) | Polymorphisms in TAS2R50 alter sensitivity to bitter compounds | NCBI Gene, ClinVar |
| Taste disorders (possible modifier) | Variants may influence individual differences in bitter taste sensitivity | OMIM, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue (taste buds) | 0.0 | Low (specific cell types) |
| Esophagus | 0.0 | Not detected |
| Small intestine | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 (transfected) | N/A | Functional expression in heterologous systems |
| Taste receptor cells (native) | N/A | Endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs1376251 | SNP | 0.25 (global) | Missense (Ala/Val); may alter receptor function |
| rs10772420 | SNP | 0.30 (global) | Intronic; no known functional effect |
Mutation functional classification
Loss of Function (LOF)
Not reported in major databases
Gain of Function (GOF)
Not reported in major databases
Dominant Negative (DN)
Not reported in major databases
View complete mutation data：
Gene Ontology (GO)
Pathways
• Taste transduction (KEGG: hsa04742)
• GPCR downstream signaling (Reactome: R-HSA-418594)
Protein Summary
TAS2R50 is a 299-amino acid transmembrane protein belonging to the T2R family of bitter taste receptors. It is a G protein-coupled receptor with seven transmembrane domains. Upon binding bitter ligands, it activates gustducin and downstream signaling cascades leading to neurotransmitter release and bitter taste perception.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R50 Knockout HEK293 Cell Line | EDJ-KQ15626 | Human | 259296 | Details Get a Quote |
| TAS2R50 Knockout HeLa Cell Line | EDJ-KQ59344 | Human | 259296 | Details Get a Quote |
| TAS2R50 Knockout A-549 Cell Line | EDJ-KQ67807 | Human | 259296 | Details Get a Quote |
| TAS2R50 Knockout HCT 116 Cell Line | EDJ-KQ76193 | Human | 259296 | Details Get a Quote |
