TAS2R5 (Taste 2 Receptor Member 5): Bitter Taste Receptor Gene
A comprehensive biomedical reference for TAS2R5, covering genomic context, expression, mutations, and clinical relevance.
Gene Information Card
| Symbol | TAS2R5 |
|---|---|
| Full Name | Taste 2 Receptor Member 5 |
| Gene Type | protein coding |
| Chromosomal Location | 7q34 |
| NCBI Gene ID | 54429 ncbi.nlm.nih.gov/gene/54429 |
| Ensembl ID | ENSG00000127399 |
| UniProt ID | Q9NYW5 |
| OMIM ID | 605062 |
| HGNC ID | 9583 |
| Aliases | T2R5, taste receptor type 2 member 5 |
Description
TAS2R5 encodes a member of the taste 2 receptor family, a group of G protein-coupled receptors that mediate bitter taste perception. The protein is expressed in taste receptor cells of the tongue and palate, where it responds to various bitter compounds, triggering a signaling cascade that leads to the perception of bitterness. TAS2R5 is also expressed in extraoral tissues, suggesting roles beyond taste, such as in the respiratory and gastrointestinal systems.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception variation | Polymorphisms in TAS2R5 may alter receptor sensitivity to bitter compounds, affecting individual taste preferences and dietary choices. | ClinVar, literature |
| Respiratory infections (potential) | TAS2R5 expression in airway smooth muscle and nasal epithelium suggests a role in innate immune responses; activation by bitter compounds may modulate bronchodilation or antimicrobial effects. | Expression studies, literature |
| Obesity (potential) | Taste receptor variants influence food intake and preference for bitter foods, potentially impacting body weight regulation. | Association studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue | Not available | High (taste buds) |
| Nasal mucosa | Not available | Moderate |
| Lung | Not available | Low |
| Gastrointestinal tract | Not available | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Taste receptor cells | Not available | Primary site of expression |
| Airway smooth muscle cells | Not available | Functional expression |
| Nasal epithelial cells | Not available | Detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs2227264 (Val216Ile) | SNP | Not determined | May alter receptor function; associated with taste sensitivity differences |
| rs2227265 (Leu236Phe) | SNP | Not determined | Potential functional impact on ligand binding |
| rs2227266 (Ile262Val) | SNP | Not determined | No known clinical significance |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations have been reported for TAS2R5 in major databases.
Gain of Function (GOF)
No gain-of-function mutations have been documented.
Dominant Negative (DN)
No dominant-negative effects have been described.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • bitter taste receptor activity |
| • plasma membrane | • signal transduction |
| • detection of chemical stimulus involved in sensory perception of bitter taste |
Pathways
• Taste transduction (KEGG: hsa04742)
• GPCR downstream signaling
Protein Summary
TAS2R5 is a 299-amino acid protein with seven transmembrane domains, characteristic of G protein-coupled receptors. It couples to the gustducin G protein complex to activate intracellular signaling pathways, leading to calcium release and neurotransmitter release. The protein is primarily localized to the plasma membrane of taste receptor cells. Structural studies suggest a binding pocket for bitter ligands, but specific agonists for TAS2R5 are not fully characterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R5 Knockout HEK293 Cell Line | EDJ-KQ11410 | Human | 54429 | Details Get a Quote |
| TAS2R50 Knockout HEK293 Cell Line | EDJ-KQ15626 | Human | 259296 | Details Get a Quote |
| TAS2R5 Knockout A-549 Cell Line | EDJ-KQ39635 | Human | 54429 | Details Get a Quote |
| TAS2R5 Knockout HCT 116 Cell Line | EDC10310 | Human | 54429 | Details Get a Quote |
| TAS2R5 Knockout HeLa Cell Line | EDJ-KQ56412 | Human | 54429 | Details Get a Quote |
| TAS2R50 Knockout HeLa Cell Line | EDJ-KQ59344 | Human | 259296 | Details Get a Quote |
| TAS2R50 Knockout A-549 Cell Line | EDJ-KQ67807 | Human | 259296 | Details Get a Quote |
| TAS2R50 Knockout HCT 116 Cell Line | EDJ-KQ76193 | Human | 259296 | Details Get a Quote |
