TAS2R46
Taste 2 Receptor Member 46
Gene Information Card
| Symbol | TAS2R46 |
|---|---|
| Full Name | Taste 2 Receptor Member 46 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 259292 ncbi.nlm.nih.gov/gene/259292 |
| Ensembl ID | ENSG00000261521 |
| UniProt ID | P59540 |
| OMIM ID | 613965 |
| HGNC ID | 18877 |
| Aliases | T2R46, T2R56, hT2R46 |
Description
TAS2R46 encodes a member of the TAS2R family of bitter taste receptors, which are G protein-coupled receptors (GPCRs) expressed primarily in taste receptor cells of the tongue and palate. This receptor responds to various bitter compounds, including denatonium and quinine, and plays a role in bitter taste perception and chemosensation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception variation | Polymorphisms in TAS2R46 alter sensitivity to bitter compounds | PMID: 20459667 |
| Upper airway infections | TAS2R46 expression in airway epithelial cells may influence innate immune responses | PMID: 24676022 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue | 0.0 | Not detected (nTPM from GTEx) |
| Salivary gland | 0.0 | Not detected |
| Lung | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | No endogenous expression; used for heterologous expression studies |
| Caco-2 | 0.0 | Not detected |
| HepG2 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs2597979 | SNP | 0.15 (global) | Missense variant (Ile191Val) may alter receptor function |
| rs11101992 | SNP | 0.05 (global) | Intronic variant; no known functional effect |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; some SNPs may reduce receptor activation by bitter ligands.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Bitter taste transduction (KEGG: hsa04742)
• GPCR downstream signaling (Reactome: R-HSA-372790)
Protein Summary
TAS2R46 is a 317-amino acid integral membrane protein with seven transmembrane domains, characteristic of GPCRs. It is expressed in taste buds and extraoral tissues, where it mediates bitter taste signaling via activation of gustducin and downstream calcium mobilization.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R46 Knockout HEK293 Cell Line | EDJ-KQ14846 | Human | 259292 | Details Get a Quote |
| TAS2R46 Knockout HeLa Cell Line | EDJ-KQ59341 | Human | 259292 | Details Get a Quote |
| TAS2R46 Knockout A-549 Cell Line | EDJ-KQ67804 | Human | 259292 | Details Get a Quote |
| TAS2R46 Knockout HCT 116 Cell Line | EDJ-KQ76190 | Human | 259292 | Details Get a Quote |
