TAS2R45: Taste 2 Receptor Member 45
Bitter taste receptor gene involved in sensory perception and potential metabolic signaling
Gene Information Card
| Symbol | TAS2R45 |
|---|---|
| Full Name | Taste 2 Receptor Member 45 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 259291 ncbi.nlm.nih.gov/gene/259291 |
| Ensembl ID | ENSG00000273136 |
| UniProt ID | P59538 |
| OMIM ID | 613966 |
| HGNC ID | 18899 |
| Aliases | T2R45, GPR59, TAS2R45, taste receptor type 2 member 45 |
Description
TAS2R45 (Taste 2 Receptor Member 45) is a protein-coding gene that belongs to the TAS2R family of bitter taste receptors. These receptors are G protein-coupled receptors (GPCRs) expressed primarily in taste receptor cells of the tongue and palate, where they detect bitter compounds. TAS2R45 has also been detected in extraoral tissues, suggesting roles beyond taste perception, such as in respiratory and gastrointestinal chemosensation. The gene is located on chromosome 12p13.2 and is intronless within the coding region.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No curated disease entries in OMIM or ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue | 0.2 | Low |
| Esophagus | 0.1 | Low |
| Stomach | 0.1 | Low |
| Small intestine | 0.1 | Low |
| Colon | 0.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not detected |
| HepG2 | 0.0 | Not detected |
| Caco-2 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs11187536 | SNV | 0.15 (global) | Missense (Ile191Val) - no known functional effect |
| rs11187537 | SNV | 0.08 (global) | Missense (Val216Ile) - no known functional effect |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function variants have been functionally characterized for TAS2R45.
Gain of Function (GOF)
No gain-of-function variants have been reported.
Dominant Negative (DN)
No dominant-negative effects have been described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Taste transduction (KEGG: hsa04742)
• GPCR downstream signaling (Reactome: R-HSA-388396)
Protein Summary
TAS2R45 encodes a 299-amino acid protein with seven transmembrane domains characteristic of GPCRs. The protein is a bitter taste receptor that couples to the G protein gustducin to activate downstream signaling cascades upon binding of bitter ligands. Expression is highest in taste buds, but low-level transcripts have been detected in several gastrointestinal and respiratory tissues. No specific ligands have been definitively identified for TAS2R45.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R45 Knockout HEK293 Cell Line | EDJ-KQ15624 | Human | 259291 | Details Get a Quote |
| TAS2R45 Knockout A-549 Cell Line | EDJ-KQ46515 | Human | 259291 | Details Get a Quote |
| TAS2R45 Knockout HCT 116 Cell Line | EDJ-KQ46516 | Human | 259291 | Details Get a Quote |
| TAS2R45 Knockout HeLa Cell Line | EDJ-KQ46517 | Human | 259291 | Details Get a Quote |
