TAS2R43
Taste 2 Receptor Member 43
Gene Information Card
| Symbol | TAS2R43 |
|---|---|
| Full Name | Taste 2 Receptor Member 43 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 259289 ncbi.nlm.nih.gov/gene/259289 |
| Ensembl ID | ENSG00000256778 |
| UniProt ID | P59537 |
| OMIM ID | 612668 |
| HGNC ID | 18862 |
| Aliases | T2R43, T2R52, TAS2R52 |
Description
TAS2R43 (Taste 2 Receptor Member 43) is a protein-coding gene that encodes a member of the bitter taste receptor family. These G protein-coupled receptors are expressed on the surface of taste receptor cells and mediate the perception of bitter compounds. TAS2R43 is known to respond to various bitter substances, including saccharin, acesulfame K, and certain plant-derived compounds. Genetic polymorphisms in TAS2R43 contribute to individual differences in bitter taste sensitivity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception variation | Polymorphisms alter receptor sensitivity to bitter compounds | NCBI Gene, ClinVar |
| Taste blindness to phenylthiocarbamide (PTC) | Non-functional variants reduce detection of PTC-like compounds | OMIM, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue (taste buds) | 0.0 | Low (specific to taste receptor cells) |
| Testis | 0.0 | Not detected |
| Small intestine | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Taste receptor cells (fungiform papillae) | N/A | Primary site of expression |
| HEK293 (heterologous expression) | N/A | Used for functional assays |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs71443637 | SNP | 0.05 (global) | Alters receptor activity |
| rs1015443 | SNP | 0.30 (global) | Associated with bitter taste sensitivity |
Mutation functional classification
Loss of Function (LOF)
rs71443637 (C>A) reduces receptor response to bitter compounds
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
Pathways
• Taste transduction (KEGG: hsa04742)
Protein Summary
TAS2R43 is a 299-amino acid G protein-coupled receptor with seven transmembrane domains. It is expressed primarily in taste receptor cells of the tongue and mediates bitter taste perception. The receptor couples to gustducin and other G proteins to activate downstream signaling cascades upon binding of bitter ligands. Polymorphisms in TAS2R43 contribute to inter-individual variability in bitter taste sensitivity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R43 Knockout HEK293 Cell Line | EDJ-KQ15623 | Human | 259289 | Details Get a Quote |
| TAS2R43 Knockout HeLa Cell Line | EDJ-KQ59339 | Human | 259289 | Details Get a Quote |
| TAS2R43 Knockout A-549 Cell Line | EDJ-KQ67802 | Human | 259289 | Details Get a Quote |
| TAS2R43 Knockout HCT 116 Cell Line | EDJ-KQ76188 | Human | 259289 | Details Get a Quote |
