TAS2R42
Taste 2 Receptor Member 42
Gene Information Card
| Symbol | TAS2R42 |
|---|---|
| Full Name | Taste 2 Receptor Member 42 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 338398 ncbi.nlm.nih.gov/gene/338398 |
| Ensembl ID | ENSG00000213903 |
| UniProt ID | Q7RTR8 |
| OMIM ID | 613967 |
| HGNC ID | 18843 |
| Aliases | T2R42, TAS2R42P (pseudogene in some annotations) |
Description
TAS2R42 encodes a member of the TAS2R family of bitter taste receptors, which are G protein-coupled receptors (GPCRs) expressed primarily in taste receptor cells of the tongue. This receptor is involved in the perception of bitter compounds and may play a role in dietary selection and toxin avoidance. The gene is located on chromosome 12p13.2 and is considered a functional receptor in some populations, though pseudogenization has been reported in certain lineages.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association confirmed | Not established | No direct evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
| Brain | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not expressed |
| HepG2 | 0.0 | Not expressed |
| K562 | 0.0 | Not expressed |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No functional studies available; pseudogenization may result in loss of function in some individuals.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • bitter taste receptor activity |
| • detection of chemical stimulus involved in sensory perception of bitter taste | • plasma membrane |
Pathways
• Gustatory transduction pathway (bitter taste signaling)
Protein Summary
TAS2R42 is a 299-amino acid protein belonging to the TAS2R family of bitter taste receptors. It is a seven-transmembrane GPCR that couples to gustducin to initiate intracellular signaling cascades upon binding of bitter ligands. The protein is predicted to localize to the plasma membrane of taste receptor cells. Functional studies are limited, and the receptor's specific ligands remain unknown.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R42 Knockout HEK293 Cell Line | EDJ-KQ15622 | Human | 353164 | Details Get a Quote |
| TAS2R42 Knockout HeLa Cell Line | EDJ-KQ59866 | Human | 353164 | Details Get a Quote |
| TAS2R42 Knockout A-549 Cell Line | EDJ-KQ68330 | Human | 353164 | Details Get a Quote |
| TAS2R42 Knockout HCT 116 Cell Line | EDJ-KQ76705 | Human | 353164 | Details Get a Quote |
