TAS2R41
Taste 2 Receptor Member 41
Gene Information Card
| Symbol | TAS2R41 |
|---|---|
| Full Name | Taste 2 Receptor Member 41 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 259287 ncbi.nlm.nih.gov/gene/259287 |
| Ensembl ID | ENSG00000221862 |
| UniProt ID | P59537 |
| OMIM ID | 613966 |
| HGNC ID | 18868 |
| Aliases | T2R41, T2R55 |
Description
TAS2R41 encodes a member of the TAS2R family of bitter taste receptors. These G protein-coupled receptors are expressed on taste receptor cells and mediate bitter taste perception. TAS2R41 is specifically activated by certain bitter compounds and contributes to the detection of potentially toxic substances in food.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception variation | Polymorphisms in TAS2R41 alter sensitivity to specific bitter compounds | Association studies (ClinVar, literature) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue (taste buds) | 0.0 | Low (specific cell types) |
| Testis | 0.0 | Not detected |
| Whole blood | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Taste receptor cells | N/A | Primary cell type |
| HEK293 | N/A | Used for functional assays |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs1376251 | SNP | 0.15 (global) | Missense (Ala55Val) – may alter ligand sensitivity |
| rs10268496 | SNP | 0.20 (global) | Intronic – no known functional effect |
Mutation functional classification
Loss of Function (LOF)
rs1376251 (Ala55Val) may reduce receptor activity for certain bitter compounds.
Gain of Function (GOF)
None reported.
Dominant Negative (DN)
None reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • bitter taste receptor activity |
| • detection of chemical stimulus involved in sensory perception of bitter taste | • plasma membrane |
Pathways
• Taste transduction (KEGG: hsa04742)
Protein Summary
TAS2R41 is a 299-amino acid transmembrane protein belonging to the TAS2R family. It functions as a bitter taste receptor, coupling to gustducin and other G proteins to initiate signaling cascades upon ligand binding. Polymorphisms in this gene contribute to interindividual differences in bitter taste sensitivity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R41 Knockout HEK293 Cell Line | EDJ-KQ15621 | Human | 259287 | Details Get a Quote |
| TAS2R41 Knockout HeLa Cell Line | EDJ-KQ59338 | Human | 259287 | Details Get a Quote |
| TAS2R41 Knockout A-549 Cell Line | EDJ-KQ67801 | Human | 259287 | Details Get a Quote |
| TAS2R41 Knockout HCT 116 Cell Line | EDJ-KQ76187 | Human | 259287 | Details Get a Quote |
