TAS2R40
Taste 2 Receptor Member 40
Gene Information Card
| Symbol | TAS2R40 |
|---|---|
| Full Name | Taste 2 Receptor Member 40 |
| Gene Type | protein-coding |
| Chromosomal Location | 7q34 |
| NCBI Gene ID | 259286 ncbi.nlm.nih.gov/gene/259286 |
| Ensembl ID | ENSG00000121377 |
| UniProt ID | P59538 |
| OMIM ID | 613967 |
| HGNC ID | 18863 |
| Aliases | T2R40, GPR60, hT2R40 |
Description
TAS2R40 (Taste 2 Receptor Member 40) is a protein-coding gene that encodes a member of the bitter taste receptor family. These receptors are G protein-coupled receptors (GPCRs) expressed primarily in taste receptor cells of the tongue and palate, where they mediate the perception of bitter compounds. TAS2R40 is involved in the detection of specific bitter tastants and may play a role in dietary selection and toxin avoidance.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception variation | Altered receptor sensitivity due to genetic variants | ClinVar, literature |
| Taste disorders (ageusia/dysgeusia) | Dysfunction of taste receptor signaling | OMIM, case reports |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue (taste buds) | 0.0 | Not quantified (specific cell type) |
| Small intestine | 0.0 | Low/absent in bulk RNA-seq |
| Testis | 0.0 | Low/absent in bulk RNA-seq |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Taste receptor cells (fungiform papillae) | N/A | Primary expression site |
| HEK293 (heterologous expression) | N/A | Used for functional assays |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs3741845 | SNP | 0.15 (global) | Alters receptor activity in vitro |
| rs7595299 | SNP | 0.08 (global) | Associated with taste sensitivity |
Mutation functional classification
Loss of Function (LOF)
rs3741845 (C allele) reduces response to bitter compounds
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
Pathways
• Bitter taste transduction (KEGG: hsa04742)
• GPCR signaling (Reactome: R-HSA-372790)
Protein Summary
TAS2R40 is a 299-amino acid integral membrane protein with seven transmembrane domains, characteristic of GPCRs. It is expressed on the surface of taste receptor cells and binds bitter compounds, initiating a signaling cascade via gustducin and downstream effectors. Structural variations in the receptor can alter ligand specificity and sensitivity, contributing to individual differences in bitter taste perception.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R40 Knockout HEK293 Cell Line | EDJ-KQ15620 | Human | 259286 | Details Get a Quote |
| TAS2R40 Knockout HeLa Cell Line | EDJ-KQ59337 | Human | 259286 | Details Get a Quote |
| TAS2R40 Knockout A-549 Cell Line | EDJ-KQ67800 | Human | 259286 | Details Get a Quote |
| TAS2R40 Knockout HCT 116 Cell Line | EDJ-KQ76186 | Human | 259286 | Details Get a Quote |
