TAS2R4
Taste 2 Receptor Member 4
Gene Information Card
| Symbol | TAS2R4 |
|---|---|
| Full Name | Taste 2 Receptor Member 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 7q34 |
| NCBI Gene ID | 50831 ncbi.nlm.nih.gov/gene/50831 |
| Ensembl ID | ENSG00000127377 |
| UniProt ID | Q9NYW3 |
| OMIM ID | 604791 |
| HGNC ID | 14913 |
| Aliases | T2R4, TRB4 |
Description
TAS2R4 (Taste 2 Receptor Member 4) is a protein-coding gene that encodes a member of the bitter taste receptor family. These G protein-coupled receptors are expressed on the surface of taste receptor cells and mediate the perception of bitterness, a key component of taste aversion and dietary selection. TAS2R4 is specifically activated by various bitter compounds, including denatonium and quinine.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception variation | Polymorphisms in TAS2R4 alter sensitivity to bitter compounds, influencing dietary preferences and potentially affecting risk for metabolic disorders. | ClinVar, literature |
| Upper aerodigestive tract cancers | Altered TAS2R4 expression in oral and pharyngeal tissues may modulate chemosensory signaling and cancer risk. | COSMIC, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue (taste buds) | 0.0 | High (specific) |
| Esophagus | 0.0 | Low |
| Stomach | 0.0 | Low |
| Small intestine | 0.0 | Low |
| Lung | 0.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Used for functional expression studies |
| Caco-2 | 0.0 | Low expression |
| HepG2 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs2233998 | SNP | 0.15 (global) | Missense (Ile191Val) - alters receptor function |
| rs2234001 | SNP | 0.10 (global) | Missense (Val96Ile) - affects bitter taste sensitivity |
| rs2234002 | SNP | 0.05 (global) | Synonymous - no known functional effect |
Mutation functional classification
Loss of Function (LOF)
rs2233998 (Ile191Val) reduces receptor activation by certain bitter compounds.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Taste transduction (KEGG: hsa04742)
• GPCR downstream signaling (Reactome: R-HSA-418594)
Protein Summary
TAS2R4 encodes a 299-amino acid G protein-coupled receptor with seven transmembrane domains. It is primarily expressed in taste receptor cells of the tongue and palate, where it binds bitter ligands and activates gustducin-mediated signaling cascades. Structural variations in TAS2R4 contribute to interindividual differences in bitter taste perception.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R4 Knockout HEK293 Cell Line | EDJ-KQ10821 | Human | 50832 | Details Get a Quote |
| TAS2R46 Knockout HEK293 Cell Line | EDJ-KQ14846 | Human | 259292 | Details Get a Quote |
| TAS2R40 Knockout HEK293 Cell Line | EDJ-KQ15620 | Human | 259286 | Details Get a Quote |
| TAS2R41 Knockout HEK293 Cell Line | EDJ-KQ15621 | Human | 259287 | Details Get a Quote |
| TAS2R42 Knockout HEK293 Cell Line | EDJ-KQ15622 | Human | 353164 | Details Get a Quote |
| TAS2R43 Knockout HEK293 Cell Line | EDJ-KQ15623 | Human | 259289 | Details Get a Quote |
| TAS2R45 Knockout HEK293 Cell Line | EDJ-KQ15624 | Human | 259291 | Details Get a Quote |
| TAS2R4 Knockout HCT 116 Cell Line | EDJ-KQ38473 | Human | 50832 | Details Get a Quote |
| TAS2R45 Knockout A-549 Cell Line | EDJ-KQ46515 | Human | 259291 | Details Get a Quote |
| TAS2R45 Knockout HCT 116 Cell Line | EDJ-KQ46516 | Human | 259291 | Details Get a Quote |
| TAS2R45 Knockout HeLa Cell Line | EDJ-KQ46517 | Human | 259291 | Details Get a Quote |
| TAS2R4 Knockout HeLa Cell Line | EDJ-KQ56189 | Human | 50832 | Details Get a Quote |
| TAS2R40 Knockout HeLa Cell Line | EDJ-KQ59337 | Human | 259286 | Details Get a Quote |
| TAS2R41 Knockout HeLa Cell Line | EDJ-KQ59338 | Human | 259287 | Details Get a Quote |
| TAS2R43 Knockout HeLa Cell Line | EDJ-KQ59339 | Human | 259289 | Details Get a Quote |
