TAS2R33 Gene - Bitter Taste Receptor Family Member
Genetic and functional insights into TAS2R33, a bitter taste receptor implicated in sensory perception and metabolic regulation.
Gene Information Card
| Symbol | TAS2R33 |
|---|---|
| Full Name | Taste 2 Receptor Member 33 |
| Gene Type | protein coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 50836 ncbi.nlm.nih.gov/gene/50836 |
| Ensembl ID | ENSG00000275221 |
| UniProt ID | P59538 |
| OMIM ID | 604796 |
| HGNC ID | 9583 |
| Aliases | T2R33, TAS2R33 |
Description
TAS2R33 encodes a member of the bitter taste receptor family, which are G protein-coupled receptors expressed primarily in taste receptor cells of the tongue and palate. These receptors detect bitter compounds, triggering a signaling cascade that results in bitter taste perception. TAS2R33 is also expressed in extraoral tissues, suggesting roles beyond taste, such as in respiratory and gastrointestinal systems.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception variation | Polymorphisms in TAS2R33 may alter receptor sensitivity to specific bitter compounds, affecting individual taste perception. | ClinVar and literature reports |
| Obesity and dietary behavior | TAS2R33 variants may influence food preferences and intake, potentially contributing to obesity risk. | Association studies in PubMed (not directly from ClinVar) |
| Respiratory infections | Expression in airway smooth muscle and nasal epithelium suggests a role in innate immunity and response to bacterial quorum-sensing molecules. | Expression studies and functional assays (not disease-specific) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue | Not available | High expression in taste buds (based on RNA-seq data from GTEx, but nTPM not specified) |
| Lung | Not available | Moderate expression in lung tissue |
| Gastrointestinal tract | Not available | Expression in stomach and intestine |
| Testis | Not available | Low expression |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Taste receptor cells | Not available | Primary site of expression |
| Airway smooth muscle cells | Not available | Functional expression in bronchial smooth muscle |
| Intestinal enteroendocrine cells | Not available | May mediate bitter sensing in gut |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs3741845 | SNP | Not available | Associated with altered bitter taste perception |
| rs3741846 | SNP | Not available | May affect receptor function |
| rs3741847 | SNP | Not available | Potential impact on ligand binding |
Mutation functional classification
Loss of Function (LOF)
Some rare variants may reduce receptor activity, leading to decreased sensitivity to certain bitter compounds.
Gain of Function (GOF)
No documented gain-of-function mutations.
Dominant Negative (DN)
Not reported for TAS2R33.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • bitter taste receptor activity |
| • signal transduction | • detection of chemical stimulus involved in sensory perception of bitter taste |
| • plasma membrane |
Pathways
• Bitter taste transduction (KEGG: hsa04742)
• GPCR downstream signaling (e.g.
• PLC-beta
• IP3
• calcium release)
Protein Summary
TAS2R33 is a 7-transmembrane G protein-coupled receptor of approximately 300 amino acids. It is activated by various bitter compounds, leading to gustducin-mediated signaling. The protein is localized to the plasma membrane and is involved in the perception of bitter taste. Structural studies suggest conserved motifs for ligand binding and G protein coupling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R33 Knockout HEK293 Cell Line | EDJ-KQ15617 | Human | 266665 | Details Get a Quote |
| TAS2R33 Knockout A-549 Cell Line | EDJ-KQ46509 | Human | 266665 | Details Get a Quote |
| TAS2R33 Knockout HCT 116 Cell Line | EDJ-KQ46510 | Human | 266665 | Details Get a Quote |
| TAS2R33 Knockout HeLa Cell Line | EDJ-KQ46511 | Human | 266665 | Details Get a Quote |
