TAS2R31
Taste 2 Receptor Member 31
Gene Information Card
| Symbol | TAS2R31 |
|---|---|
| Full Name | Taste 2 Receptor Member 31 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 259290 ncbi.nlm.nih.gov/gene/259290 |
| Ensembl ID | ENSG00000256778 |
| UniProt ID | P59538 |
| OMIM ID | 613961 |
| HGNC ID | 18821 |
| Aliases | T2R31, TAS2R44, T2R44, TAS2R53, T2R53 |
Description
TAS2R31 encodes a member of the TAS2R family of bitter taste receptors, which are G protein-coupled receptors expressed on taste receptor cells. This receptor responds to various bitter compounds, including saccharin and acesulfame K, and plays a role in the perception of bitterness.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception variation | Polymorphisms in TAS2R31 alter sensitivity to bitter compounds | NCBI Gene, ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue (taste buds) | 0.0 | Low |
| Salivary gland | 0.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Taste receptor cells | 0.0 | Expressed in subset of taste cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs10772420 | SNP | 0.3 | Alters bitter taste sensitivity to saccharin |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function variants reduce sensitivity to certain bitter compounds.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • bitter taste receptor activity |
| • detection of chemical stimulus involved in sensory perception of bitter taste |
Pathways
• Taste transduction (KEGG: hsa04742)
Protein Summary
TAS2R31 is a 299-amino acid transmembrane protein belonging to the TAS2R family. It functions as a bitter taste receptor, coupling to gustducin to activate downstream signaling upon binding bitter ligands.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R31 Knockout HEK293 Cell Line | EDJ-KQ15616 | Human | 259290 | Details Get a Quote |
| TAS2R31 Knockout HeLa Cell Line | EDJ-KQ59340 | Human | 259290 | Details Get a Quote |
| TAS2R31 Knockout A-549 Cell Line | EDJ-KQ67803 | Human | 259290 | Details Get a Quote |
| TAS2R31 Knockout HCT 116 Cell Line | EDJ-KQ76189 | Human | 259290 | Details Get a Quote |
