TAS2R30
Taste 2 Receptor Member 30
Gene Information Card
| Symbol | TAS2R30 |
|---|---|
| Full Name | Taste 2 Receptor Member 30 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 259293 ncbi.nlm.nih.gov/gene/259293 |
| Ensembl ID | ENSG00000273136 |
| UniProt ID | P59543 |
| OMIM ID | 613964 |
| HGNC ID | 18827 |
| Aliases | T2R30, TAS2R47, T2R47 |
Description
TAS2R30 encodes a member of the TAS2R family of bitter taste receptors, which are G protein-coupled receptors expressed primarily in taste receptor cells of the tongue. This receptor mediates bitter taste perception in response to various bitter compounds.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception variation | Polymorphisms in TAS2R30 alter sensitivity to bitter compounds | Association studies (NCBI, OMIM) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
| Esophagus | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | No endogenous expression |
| Caco-2 | 0.0 | No endogenous expression |
| HepG2 | 0.0 | No endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs724160 | SNP | 0.15 (global) | Alters bitter taste sensitivity |
Mutation functional classification
Loss of Function (LOF)
Not reported
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • bitter taste receptor activity |
| • detection of chemical stimulus involved in sensory perception of bitter taste | • plasma membrane |
Pathways
• Gustatory signaling pathway (bitter taste transduction)
Protein Summary
TAS2R30 is a 299-amino acid transmembrane protein belonging to the TAS2R family. It functions as a bitter taste receptor, coupling to gustducin and other G proteins to initiate signaling cascades in response to bitter ligands.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R30 Knockout HEK293 Cell Line | EDJ-KQ15615 | Human | 259293 | Details Get a Quote |
| TAS2R30 Knockout HeLa Cell Line | EDJ-KQ59342 | Human | 259293 | Details Get a Quote |
| TAS2R30 Knockout A-549 Cell Line | EDJ-KQ67805 | Human | 259293 | Details Get a Quote |
| TAS2R30 Knockout HCT 116 Cell Line | EDJ-KQ76191 | Human | 259293 | Details Get a Quote |
