TAS2R3: Taste 2 Receptor Member 3
Bitter Taste Receptor Gene Involved in Chemosensory Perception
Gene Information Card
| Symbol | TAS2R3 |
|---|---|
| Full Name | Taste 2 Receptor Member 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 50831 ncbi.nlm.nih.gov/gene/50831 |
| Ensembl ID | ENSG00000127399 |
| UniProt ID | Q9NYW0 |
| OMIM ID | 604868 |
| HGNC ID | 14910 |
| Aliases | T2R3, T2R03, TAS2R3 |
Description
TAS2R3 (Taste 2 Receptor Member 3) is a protein-coding gene that encodes a member of the bitter taste receptor family. These G protein-coupled receptors are expressed on the surface of taste receptor cells and mediate the perception of bitter compounds, playing a role in food selection and avoidance of potentially toxic substances.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception variation | Polymorphisms in TAS2R3 alter receptor sensitivity to specific bitter compounds | NCBI Gene, ClinVar |
| Obesity (potential association) | Variants in bitter taste receptor genes may influence dietary preferences and energy intake | OMIM, PubMed |
| Alcohol dependence (suggested) | Bitter taste sensitivity may affect alcohol consumption behavior | OMIM, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue (taste buds) | 0.0 | Low (specific cell types) |
| Esophagus | 0.0 | Low |
| Stomach | 0.0 | Low |
| Small intestine | 0.0 | Low |
| Colon | 0.0 | Low |
| Testis | 0.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Taste receptor cells | N/A | Primary cell type |
| HEK293 (transfected) | N/A | Model system for functional studies |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs765007 | SNP | 0.15 (global) | Missense variant (Cys>Arg) may alter receptor function |
| rs11762213 | SNP | 0.10 (global) | Intronic variant with unknown effect |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; some SNPs may reduce receptor activation
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • bitter taste receptor activity |
| • detection of chemical stimulus involved in sensory perception of bitter taste | • plasma membrane |
| • signal transduction |
Pathways
• Taste transduction (KEGG: hsa04742)
• GPCR downstream signaling
Protein Summary
The TAS2R3 protein is a 314-amino acid G protein-coupled receptor with seven transmembrane domains. It is expressed in taste receptor cells and binds to various bitter compounds, initiating a signaling cascade that leads to the perception of bitterness. Polymorphisms in this gene contribute to individual differences in bitter taste sensitivity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R38 Knockout HEK293 Cell Line | EDJ-KQ5585 | Human | 5726 | Details Get a Quote |
| TAS2R3 Knockout HEK293 Cell Line | EDJ-KQ10820 | Human | 50831 | Details Get a Quote |
| TAS2R30 Knockout HEK293 Cell Line | EDJ-KQ15615 | Human | 259293 | Details Get a Quote |
| TAS2R31 Knockout HEK293 Cell Line | EDJ-KQ15616 | Human | 259290 | Details Get a Quote |
| TAS2R33 Knockout HEK293 Cell Line | EDJ-KQ15617 | Human | 266665 | Details Get a Quote |
| TAS2R36 Knockout HEK293 Cell Line | EDJ-KQ15618 | Human | 266666 | Details Get a Quote |
| TAS2R39 Knockout HEK293 Cell Line | EDJ-KQ15619 | Human | 259285 | Details Get a Quote |
| TAS2R36 Knockout HeLa Cell Line | EDJ-KQ45286 | Human | 266666 | Details Get a Quote |
| TAS2R33 Knockout A-549 Cell Line | EDJ-KQ46509 | Human | 266665 | Details Get a Quote |
| TAS2R33 Knockout HCT 116 Cell Line | EDJ-KQ46510 | Human | 266665 | Details Get a Quote |
| TAS2R33 Knockout HeLa Cell Line | EDJ-KQ46511 | Human | 266665 | Details Get a Quote |
| TAS2R36 Knockout A-549 Cell Line | EDJ-KQ46512 | Human | 266666 | Details Get a Quote |
| TAS2R36 Knockout HCT 116 Cell Line | EDJ-KQ46513 | Human | 266666 | Details Get a Quote |
| TAS2R38 Knockout HeLa Cell Line | EDJ-KQ54252 | Human | 5726 | Details Get a Quote |
| TAS2R3 Knockout HeLa Cell Line | EDJ-KQ56188 | Human | 50831 | Details Get a Quote |
