TAS2R20
Taste 2 Receptor Member 20
Gene Information Card
| Symbol | TAS2R20 |
|---|---|
| Full Name | Taste 2 Receptor Member 20 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 259294 ncbi.nlm.nih.gov/gene/259294 |
| Ensembl ID | ENSG00000212127 |
| UniProt ID | P59543 |
| OMIM ID | 613966 |
| HGNC ID | 14920 |
| Aliases | T2R20, T2R56, TAS2R56 |
Description
TAS2R20 encodes a member of the taste 2 receptor family of G protein-coupled receptors (GPCRs). These receptors are expressed on the surface of taste receptor cells and mediate bitter taste perception. TAS2R20 is specifically activated by bitter compounds such as denatonium and quinine. The gene is located on chromosome 12p13.2 within a cluster of bitter taste receptor genes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception (normal variation) | Receptor activation by bitter ligands; polymorphisms may alter sensitivity | NCBI, UniProt |
| No specific disease associations reported | Not applicable | ClinVar, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue (taste buds) | Not quantified (nTPM not available) | High (specific) |
| Testis | 0.4 | Low |
| Esophagus | 0.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 (heterologous expression) | Not applicable | Used for functional assays |
| Taste receptor cells (native) | Not applicable | Endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs12033832 (c.166G>A, p.Val56Ile) | SNP | 0.15 (global) | Alters ligand sensitivity (in vitro) |
| rs10845287 (c.785C>T, p.Thr262Met) | SNP | 0.08 (global) | Reduced receptor activity |
Mutation functional classification
Loss of Function (LOF)
rs10845287 (Thr262Met) reduces receptor activation by bitter compounds.
Gain of Function (GOF)
None reported.
Dominant Negative (DN)
None reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • bitter taste receptor activity (GO:0033038) |
| • taste transduction (GO:0050913) | • plasma membrane (GO:0005886) |
Pathways
• Taste transduction (KEGG: hsa04742)
Protein Summary
TAS2R20 is a 299-amino acid GPCR with seven transmembrane domains. It functions as a bitter taste receptor, coupling to the G protein gustducin to activate downstream signaling. The protein is primarily expressed in taste receptor cells of the tongue, where it detects a range of bitter compounds. Polymorphisms in TAS2R20 contribute to interindividual differences in bitter taste sensitivity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R20 Knockout HEK293 Cell Line | EDJ-KQ15614 | Human | 259295 | Details Get a Quote |
| TAS2R20 Knockout HeLa Cell Line | EDJ-KQ45279 | Human | 259295 | Details Get a Quote |
| TAS2R20 Knockout A-549 Cell Line | EDJ-KQ46506 | Human | 259295 | Details Get a Quote |
| TAS2R20 Knockout HCT 116 Cell Line | EDJ-KQ46507 | Human | 259295 | Details Get a Quote |
