TAS2R19
Taste 2 Receptor Member 19
Gene Information Card
| Symbol | TAS2R19 |
|---|---|
| Full Name | Taste 2 Receptor Member 19 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 259294 ncbi.nlm.nih.gov/gene/259294 |
| Ensembl ID | ENSG00000212127 |
| UniProt ID | P59542 |
| OMIM ID | 613966 |
| HGNC ID | 18827 |
| Aliases | T2R19, T2R48, TAS2R48, TAS2R19P |
Description
TAS2R19 encodes a member of the TAS2R family of bitter taste receptors, which are G protein-coupled receptors expressed on taste receptor cells. This receptor mediates bitter taste perception and may play a role in dietary preferences and avoidance of toxic compounds.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception variation | Polymorphisms in TAS2R19 alter receptor sensitivity to bitter compounds | PMID: 22968131 |
| Dietary behavior and obesity risk | Genetic variation in TAS2R19 influences food preferences and energy intake | PMID: 25646333 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue (taste buds) | 0.0 | Low (specific cell types) |
| Small intestine | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | No endogenous expression |
| Taste bud cells (HTC-8) | 0.0 | Not available |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs10772420 (C>A) | SNV | 0.15 (global) | Alters receptor function; associated with bitter taste sensitivity |
| rs1867098 (G>A) | SNV | 0.10 (global) | Missense; reduced response to bitter ligands |
Mutation functional classification
Loss of Function (LOF)
rs1867098 (G>A) reduces receptor activation by bitter compounds.
Gain of Function (GOF)
No known gain-of-function variants.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Taste transduction (KEGG: hsa04742)
• GPCR downstream signaling (Reactome: R-HSA-418594)
Protein Summary
TAS2R19 is a 299-amino acid transmembrane protein belonging to the TAS2R family. It functions as a bitter taste receptor, coupling to gustducin and activating downstream signaling cascades upon ligand binding. Structural variations influence individual differences in bitter taste perception.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R19 Knockout HEK293 Cell Line | EDJ-KQ15613 | Human | 259294 | Details Get a Quote |
| TAS2R19 Knockout HeLa Cell Line | EDJ-KQ59343 | Human | 259294 | Details Get a Quote |
| TAS2R19 Knockout A-549 Cell Line | EDJ-KQ67806 | Human | 259294 | Details Get a Quote |
| TAS2R19 Knockout HCT 116 Cell Line | EDJ-KQ76192 | Human | 259294 | Details Get a Quote |
