TAS2R13
Taste 2 Receptor Member 13
Gene Information Card
| Symbol | TAS2R13 |
|---|---|
| Full Name | Taste 2 Receptor Member 13 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 50838 ncbi.nlm.nih.gov/gene/50838 |
| Ensembl ID | ENSG00000212127 |
| UniProt ID | Q9NYV9 |
| OMIM ID | 604796 |
| HGNC ID | 14919 |
| Aliases | T2R13, TAS2R13, taste receptor type 2 member 13 |
Description
TAS2R13 (Taste 2 Receptor Member 13) is a protein-coding gene located on chromosome 12p13.2. It encodes a member of the bitter taste receptor family (T2Rs), which are G protein-coupled receptors (GPCRs) expressed primarily in taste receptor cells of the tongue and palate. TAS2R13 mediates the perception of bitter compounds, playing a role in detecting potentially toxic substances and influencing dietary preferences. Genetic variants in TAS2R13 have been associated with individual differences in bitter taste sensitivity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste sensitivity variation | Polymorphisms in TAS2R13 alter receptor function, affecting perception of bitter compounds | Association studies (NCBI, ClinVar) |
| Obesity (potential modifier) | Variants may influence food preferences and caloric intake via bitter taste perception | Observational studies (PubMed) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue (taste buds) | Not quantified (nTPM not applicable) | High (specific expression) |
| Testis | 0.2 | Low |
| Small intestine | 0.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK-293 (heterologous expression) | Not quantified | Used for functional assays |
| Taste receptor cells (primary) | Not quantified | Endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs1015443 (C>T) | SNP | 0.3 (global) | Alters receptor activity; associated with bitter taste sensitivity |
| rs713598 (G>A) | SNP | 0.4 (global) | Missense variant; affects ligand binding |
Mutation functional classification
Loss of Function (LOF)
rs1015443 (C>T) reduces receptor response to bitter compounds
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
Pathways
• Taste transduction (KEGG: hsa04742)
• GPCR downstream signaling (Reactome: R-HSA-372790)
Protein Summary
TAS2R13 encodes a 299-amino acid protein (UniProt Q9NYV9) with seven transmembrane domains characteristic of GPCRs. It is expressed on the surface of taste receptor cells and binds bitter compounds, initiating a signaling cascade via gustducin and downstream effectors. The protein is involved in the detection of a wide range of bitter substances, including plant alkaloids and synthetic chemicals.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R13 Knockout HEK293 Cell Line | EDJ-KQ10829 | Human | 50838 | Details Get a Quote |
| TAS2R13 Knockout HeLa Cell Line | EDJ-KQ56195 | Human | 50838 | Details Get a Quote |
| TAS2R13 Knockout A-549 Cell Line | EDJ-KQ64684 | Human | 50838 | Details Get a Quote |
| TAS2R13 Knockout HCT 116 Cell Line | EDJ-KQ73132 | Human | 50838 | Details Get a Quote |
