TAS2R10
Taste 2 Receptor Member 10
Gene Information Card
| Symbol | TAS2R10 |
|---|---|
| Full Name | Taste 2 Receptor Member 10 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p13.2 |
| NCBI Gene ID | 50839 ncbi.nlm.nih.gov/gene/50839 |
| Ensembl ID | ENSG00000128519 |
| UniProt ID | Q9NYW0 |
| OMIM ID | 604791 |
| HGNC ID | 14918 |
| Aliases | T2R10, TRB2 |
Description
TAS2R10 (Taste 2 Receptor Member 10) is a protein-coding gene that encodes a bitter taste receptor. This receptor is a member of the G protein-coupled receptor (GPCR) family and is involved in the perception of bitter compounds. The gene is located on chromosome 12p13.2 and is expressed in taste receptor cells of the tongue and in extraoral tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception variation | Polymorphisms in TAS2R10 alter sensitivity to bitter compounds | PMID: 15744041 |
| Obesity | TAS2R10 variants may influence dietary preferences and body mass index | PMID: 25646336 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue | 0.0 | Not detected (nTPM < 1) |
| Esophagus | 0.0 | Not detected |
| Small intestine | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not expressed |
| HepG2 | 0.0 | Not expressed |
| A549 | 0.0 | Not expressed |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs2270009 | SNP | 0.15 (global) | Missense (Ile191Val) |
| rs2270010 | SNP | 0.10 (global) | Missense (Ala227Thr) |
Mutation functional classification
Loss of Function (LOF)
rs2270009 (Ile191Val) may reduce receptor activity
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
Pathways
• Taste transduction (KEGG: hsa04742)
• GPCR downstream signaling (Reactome: R-HSA-388396)
Protein Summary
The TAS2R10 protein is a 317-amino acid transmembrane receptor belonging to the TAS2R family of bitter taste receptors. It is a GPCR that couples to gustducin and mediates bitter taste perception. The protein is primarily localized to the plasma membrane of taste receptor cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R10 Knockout HEK293 Cell Line | EDJ-KQ10826 | Human | 50839 | Details Get a Quote |
| TAS2R10 Knockout HeLa Cell Line | EDJ-KQ38474 | Human | 50839 | Details Get a Quote |
| TAS2R10 Knockout A-549 Cell Line | EDJ-KQ64685 | Human | 50839 | Details Get a Quote |
| TAS2R10 Knockout HCT 116 Cell Line | EDJ-KQ73133 | Human | 50839 | Details Get a Quote |
