TAS2R1
Taste 2 Receptor Member 1
Gene Information Card
| Symbol | TAS2R1 |
|---|---|
| Full Name | Taste 2 Receptor Member 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 5p15.31 |
| NCBI Gene ID | 50834 ncbi.nlm.nih.gov/gene/50834 |
| Ensembl ID | ENSG00000169738 |
| UniProt ID | Q9NYW0 |
| OMIM ID | 604796 |
| HGNC ID | 9589 |
| Aliases | T2R1, TRB7, GPR71 |
Description
TAS2R1 encodes a member of the TAS2R family of bitter taste receptors, which are G protein-coupled receptors (GPCRs) expressed primarily in taste receptor cells of the tongue and palate. This receptor mediates perception of bitter compounds, including natural toxins and synthetic chemicals, and is involved in innate avoidance behavior.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Bitter taste perception (normal variation) | Polymorphisms in TAS2R1 alter sensitivity to bitter compounds such as phenylthiocarbamide (PTC) and propylthiouracil (PROP). | PMID: 12508121, ClinVar |
| Chronic rhinosinusitis | TAS2R1 expression in sinonasal epithelium may modulate innate immune responses and inflammation. | PMID: 24628823 |
| Upper respiratory tract infections | Bitter taste receptors in airway epithelia detect bacterial quorum-sensing molecules, triggering antimicrobial responses. | PMID: 24628823 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tongue (taste buds) | 0.0 | Not quantified in GTEx (taste-specific) |
| Nasal epithelium | 0.0 | Not quantified in GTEx |
| Lung | 0.0 | Not quantified in GTEx |
| Testis | 0.0 | Not quantified in GTEx |
| Thyroid | 0.0 | Not quantified in GTEx |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 (transfected) | N/A | Functional expression used for ligand assays |
| HNEpC (human nasal epithelial cells) | N/A | Endogenous expression detected by RT-PCR |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs4144566 (c.145G>A, p.Ala49Thr) | SNP | 0.15 (global) | Alters bitter taste sensitivity |
| rs2233998 (c.785C>T, p.Thr262Ile) | SNP | 0.10 (global) | Associated with reduced receptor activity |
| rs2233999 (c.886G>A, p.Val296Ile) | SNP | 0.08 (global) | May affect ligand binding |
Mutation functional classification
Loss of Function (LOF)
rs2233998 (Thr262Ile) reduces receptor activation by bitter compounds.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
Not described for TAS2R1.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Taste transduction (KEGG: hsa04742)
• GPCR downstream signaling (Reactome: R-HSA-418594)
Protein Summary
TAS2R1 is a 299-amino acid, 7-transmembrane G protein-coupled receptor (GPCR) belonging to the TAS2R family. It is expressed in taste buds and extraoral tissues (e.g., nasal epithelium, lung). Upon binding bitter ligands (e.g., denatonium, quinine), it activates gustducin and downstream signaling cascades leading to calcium mobilization and neurotransmitter release. Polymorphisms influence individual differences in bitter taste perception and may modulate innate immune responses in the airways.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAS2R16 Knockout HEK293 Cell Line | EDJ-KQ10822 | Human | 50833 | Details Get a Quote |
| TAS2R10 Knockout HEK293 Cell Line | EDJ-KQ10826 | Human | 50839 | Details Get a Quote |
| TAS2R14 Knockout HEK293 Cell Line | EDJ-KQ10827 | Human | 50840 | Details Get a Quote |
| TAS2R1 Knockout HEK293 Cell Line | EDJ-KQ10828 | Human | 50834 | Details Get a Quote |
| TAS2R13 Knockout HEK293 Cell Line | EDJ-KQ10829 | Human | 50838 | Details Get a Quote |
| TAS2R19 Knockout HEK293 Cell Line | EDJ-KQ15613 | Human | 259294 | Details Get a Quote |
| TAS2R10 Knockout HeLa Cell Line | EDJ-KQ38474 | Human | 50839 | Details Get a Quote |
| TAS2R14 Knockout A-549 Cell Line | EDJ-KQ38475 | Human | 50840 | Details Get a Quote |
| TAS2R14 Knockout HCT 116 Cell Line | EDJ-KQ38476 | Human | 50840 | Details Get a Quote |
| TAS2R14 Knockout HeLa Cell Line | EDJ-KQ38477 | Human | 50840 | Details Get a Quote |
| TAS2R16 Knockout HeLa Cell Line | EDJ-KQ56190 | Human | 50833 | Details Get a Quote |
| TAS2R1 Knockout HeLa Cell Line | EDJ-KQ56191 | Human | 50834 | Details Get a Quote |
| TAS2R13 Knockout HeLa Cell Line | EDJ-KQ56195 | Human | 50838 | Details Get a Quote |
| TAS2R19 Knockout HeLa Cell Line | EDJ-KQ59343 | Human | 259294 | Details Get a Quote |
| TAS2R16 Knockout A-549 Cell Line | EDJ-KQ64679 | Human | 50833 | Details Get a Quote |
