TARBP1
TAR (HIV-1) RNA Binding Protein 1
Gene Information Card
| Symbol | TARBP1 |
|---|---|
| Full Name | TAR (HIV-1) RNA Binding Protein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q42.2 |
| NCBI Gene ID | 6894 ncbi.nlm.nih.gov/gene/6894 |
| Ensembl ID | ENSG00000143178 |
| UniProt ID | Q13395 |
| OMIM ID | 605052 |
| HGNC ID | 11569 |
| Aliases | TRBP1, TRBP, TARBP1 |
Description
TARBP1 encodes a protein that binds to the trans-activation response (TAR) element of HIV-1 RNA. It is involved in RNA metabolism, including microRNA processing and translational regulation. The gene is located on chromosome 1q42.2 and is expressed in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not applicable | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.5 | Low |
| Lung | 6.2 | Low |
| Liver | 4.1 | Low |
| Kidney | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.1 | Moderate expression |
| HeLa | 7.5 | Low expression |
| K562 | 5.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • RNA binding | • double-stranded RNA binding |
| • protein binding | • cytoplasm |
| • nucleus |
Pathways
• HIV-1 lifecycle
• miRNA biogenesis
Protein Summary
TARBP1 is a 366-amino acid protein that contains two double-stranded RNA-binding domains. It interacts with Dicer and is involved in the processing of microRNAs. It also binds to the HIV-1 TAR element, influencing viral replication.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TARBP1 Knockout HEK293 Cell Line | EDJ-KQ5885 | Human | 6894 | Details Get a Quote |
| TARBP1 Knockout A-549 Cell Line | EDJ-KQ29381 | Human | 6894 | Details Get a Quote |
| TARBP1 Knockout HCT 116 Cell Line | EDJ-KQ29382 | Human | 6894 | Details Get a Quote |
| TARBP1 Knockout HeLa Cell Line | EDJ-KQ29383 | Human | 6894 | Details Get a Quote |
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