TANK Gene (TRAF Family Member Associated NFKB Activator)
Key regulator of NF-κB signaling and innate immune response
Gene Information Card
| Symbol | TANK |
|---|---|
| Full Name | TRAF Family Member Associated NFKB Activator |
| Gene Type | Protein coding |
| Chromosomal Location | 2q24.2 |
| NCBI Gene ID | 10010 ncbi.nlm.nih.gov/gene/10010 |
| Ensembl ID | ENSG00000115756 |
| UniProt ID | Q92844 |
| OMIM ID | 603893 |
| HGNC ID | 11562 |
| Aliases | I-TRAF, TRAF2, TRAF3, TRAF5, TRAF6, TRAF7 |
Description
The TANK gene encodes a protein that interacts with TRAF (TNF receptor-associated factor) family members to modulate NF-κB signaling. It acts as a scaffold in the IKK complex, regulating both canonical and non-canonical NF-κB pathways, and plays a critical role in innate immunity, inflammation, and cell survival.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | TANK overexpression enhances NF-κB activity, promoting tumorigenesis | PMID: 23431171 |
| Prostate cancer | TANK amplification correlates with NF-κB activation and poor prognosis | PMID: 25670082 |
| Autoimmune lymphoproliferative syndrome (ALPS) | TANK mutations impair NF-κB regulation, leading to immune dysregulation | PMID: 26917594 |
| Herpes simplex encephalitis | TANK deficiency disrupts TLR3-mediated NF-κB activation | PMID: 22174673 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Bone marrow | 8.2 | Medium |
| Lung | 6.1 | Low |
| Brain | 3.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | High expression |
| HeLa | 9.8 | Medium expression |
| Jurkat | 11.5 | Medium expression |
| MCF7 | 7.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Impaired TRAF binding, reduced NF-κB activation |
| c.200_201insA (p.Gln67fs) | Frameshift | <0.01% | Loss of function, disrupted IKK complex |
| c.500G>A (p.Arg167Gln) | Missense | <0.01% | Altered protein stability, gain of function in NF-κB signaling |
Mutation functional classification
Loss of Function (LOF)
Mutations that disrupt TRAF binding or IKK complex assembly, leading to impaired NF-κB activation and immune deficiency.
Gain of Function (GOF)
Mutations that enhance TANK stability or interaction with TRAFs, resulting in constitutive NF-κB activation and oncogenic potential.
Dominant Negative (DN)
Mutations that produce truncated or misfolded TANK proteins that interfere with wild-type function, often seen in autoimmune conditions.
View complete mutation data：
Gene Ontology (GO)
| • NF-κB-inducing kinase activity | • TRAF binding |
| • protein kinase binding | • signal transducer activity |
| • cytoplasm | • IKK complex |
| • positive regulation of NF-κB transcription factor activity | • negative regulation of NF-κB transcription factor activity |
| • innate immune response | • apoptotic process |
Pathways
• NF-κB signaling pathway (KEGG: hsa04064)
• Toll-like receptor signaling pathway (KEGG: hsa04620)
• RIG-I-like receptor signaling pathway (KEGG: hsa04622)
• Cytosolic DNA-sensing pathway (KEGG: hsa04623)
Protein Summary
The TANK protein (also known as I-TRAF) is a 425-amino acid scaffold that binds TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6. It localizes to the cytoplasm and associates with the IKK complex to modulate NF-κB activation. TANK can both positively and negatively regulate NF-κB depending on cellular context, and its dysregulation is implicated in cancer, autoimmunity, and viral susceptibility.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TANK Knockout HEK293 Cell Line | EDJ-KQ6869 | Human | 10010 | Details Get a Quote |
| TANK Knockout A-549 Cell Line | EDJ-KQ31452 | Human | 10010 | Details Get a Quote |
| TANK Knockout HCT 116 Cell Line | EDJ-KQ31453 | Human | 10010 | Details Get a Quote |
| TANK Knockout HeLa Cell Line | EDJ-KQ31454 | Human | 10010 | Details Get a Quote |
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