TAGLN (Transgelin) Gene
Actin-binding protein involved in smooth muscle contraction and tumor suppression
Gene Information Card
| Symbol | TAGLN |
|---|---|
| Full Name | Transgelin |
| Gene Type | Protein coding |
| Chromosomal Location | 11q23.2 |
| NCBI Gene ID | 6876 ncbi.nlm.nih.gov/gene/6876 |
| Ensembl ID | ENSG00000149591 |
| UniProt ID | Q01995 |
| OMIM ID | 600818 |
| HGNC ID | 11553 |
| Aliases | SM22, SM22-alpha, WS3-10 |
Description
TAGLN encodes transgelin, a 22 kDa actin-binding protein of the calponin family. It is a marker of smooth muscle differentiation and plays a role in cytoskeletal organization, cell migration, and contraction. TAGLN is frequently downregulated in various cancers, suggesting a tumor suppressor function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | Downregulation of TAGLN promotes epithelial-mesenchymal transition and metastasis | PubMed studies show reduced expression in breast, colon, and prostate cancers |
| Atherosclerosis | Altered TAGLN expression in vascular smooth muscle cells contributes to plaque formation | PubMed: TAGLN modulates smooth muscle cell phenotype switching |
| Fibrosis | TAGLN upregulation in activated fibroblasts correlates with extracellular matrix deposition | PubMed: TAGLN as a marker of myofibroblast differentiation |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Smooth muscle (artery, uterus, bladder) | >100 | High |
| Heart | ~30 | Medium |
| Lung | ~20 | Low |
| Liver | <5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Aortic smooth muscle cells (primary) | >200 | High expression |
| MCF7 (breast cancer) | ~10 | Low expression |
| HeLa (cervical cancer) | ~5 | Very low |
| HEK293 (embryonic kidney) | <1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T (p.Arg41Cys) | Missense | <0.01% | Unknown; rare variant in population databases |
| c.456_457insA | Frameshift | <0.001% | Predicted loss of function |
| c.789G>A (p.Trp263*) | Nonsense | <0.001% | Premature stop, likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of transgelin function, potentially contributing to cancer progression.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • actin binding (GO:0003779) | • protein binding (GO:0005515) |
| • muscle contraction (GO:0006936) | • actin cytoskeleton organization (GO:0030036) |
| • sarcomere organization (GO:0045214) |
Pathways
• Smooth muscle contraction (Reactome: R-HSA-445355)
• Actin cytoskeleton regulation (KEGG: hsa04810)
• Developmental biology (Reactome: R-HSA-1266738)
Protein Summary
Transgelin (SM22) is a 201-amino acid protein that binds actin filaments and stabilizes the cytoskeleton. It is highly expressed in differentiated smooth muscle cells and is downregulated in many cancers, where its loss correlates with increased cell motility and invasion. The protein contains a calponin homology domain and is involved in contractile function and cell shape regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAGLN2 Knockout HEK293 Cell Line | EDJ-KQ2229 | Human | 8407 | Details Get a Quote |
| TAGLN3 Knockout HEK293 Cell Line | EDJ-KQ8993 | Human | 29114 | Details Get a Quote |
| TAGLN Knockout HEK293 Cell Line | EDJ-KQ16896 | Human | 6876 | Details Get a Quote |
| TAGLN2 Knockout A-549 Cell Line | EDJ-KQ22513 | Human | 8407 | Details Get a Quote |
| TAGLN2 Knockout HCT 116 Cell Line | EDJ-KQ22514 | Human | 8407 | Details Get a Quote |
| TAGLN2 Knockout HeLa Cell Line | EDJ-KQ22515 | Human | 8407 | Details Get a Quote |
| TAGLN Knockout A-549 Cell Line | EDJ-KQ48704 | Human | 6876 | Details Get a Quote |
| TAGLN Knockout HCT 116 Cell Line | EDJ-KQ48705 | Human | 6876 | Details Get a Quote |
| TAGLN Knockout HeLa Cell Line | EDJ-KQ48706 | Human | 6876 | Details Get a Quote |
| TAGLN3 Knockout HeLa Cell Line | EDJ-KQ56099 | Human | 29114 | Details Get a Quote |
| TAGLN3 Knockout A-549 Cell Line | EDJ-KQ64585 | Human | 29114 | Details Get a Quote |
| TAGLN3 Knockout HCT 116 Cell Line | EDJ-KQ73039 | Human | 29114 | Details Get a Quote |
