TAFA4
Chemokine-like protein involved in neuroimmune modulation and pain signaling
Gene Information Card
| Symbol | TAFA4 |
|---|---|
| Full Name | TAFA chemokine like family member 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 3p14.1 |
| NCBI Gene ID | 340895 ncbi.nlm.nih.gov/gene/340895 |
| Ensembl ID | ENSG00000163874 |
| UniProt ID | Q96LR4 |
| OMIM ID | 617495 |
| HGNC ID | 25000 |
| Aliases | FAM19A4, TAFA-4 |
Description
TAFA4 (TAFA chemokine like family member 4) encodes a small secreted protein belonging to the TAFA family, which shares structural homology with chemokines. The protein is predominantly expressed in the nervous system and modulates neuroimmune interactions, particularly in sensory neurons and microglia. It is involved in pain processing, neuronal survival, and immune cell recruitment.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neuropathic pain | TAFA4 modulates microglial activation and neuronal sensitization in dorsal root ganglia | PMID: 25788674 |
| Chronic pain conditions | Altered TAFA4 expression correlates with pain severity in rodent models | PMID: 25788674 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 0.8 | Low |
| Spinal cord | 1.2 | Low |
| Testis | 0.3 | Not detected |
| Spleen | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 0.5 | Neuronal cell line |
| U-87 MG | 0.2 | Glioblastoma cell line |
| HEK293 | 0.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.202C>T | Missense | <0.01% | p.Arg68Cys; predicted benign |
| c.315G>A | Missense | <0.01% | p.Trp105*; predicted loss-of-function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutation p.Trp105* likely leads to truncated protein and loss of function.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity | • extracellular region |
| • signal transduction | • immune response |
| • positive regulation of neurogenesis |
Pathways
• Chemokine signaling pathway
• Neuroactive ligand-receptor interaction
Protein Summary
TAFA4 is a 140-amino-acid secreted protein with a signal peptide and a conserved TAFA domain. It binds to unknown receptors to regulate neuronal survival, microglial chemotaxis, and pain transmission. The protein is primarily expressed in the central nervous system and peripheral sensory neurons.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAFA4 Knockout HEK293 Cell Line | EDJ-KQ11345 | Human | 151647 | Details Get a Quote |
| TAFA4 Knockout HeLa Cell Line | EDJ-KQ58691 | Human | 151647 | Details Get a Quote |
| TAFA4 Knockout A-549 Cell Line | EDJ-KQ67174 | Human | 151647 | Details Get a Quote |
| TAFA4 Knockout HCT 116 Cell Line | EDJ-KQ75576 | Human | 151647 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
