TAF11L9: TATA-Box Binding Protein Associated Factor 11 Like 9
A poorly characterized member of the TAF11 family with potential roles in transcriptional regulation and cancer.
Gene Information Card
| Symbol | TAF11L9 |
|---|---|
| Full Name | TATA-box binding protein associated factor 11 like 9 |
| Gene Type | protein coding |
| Chromosomal Location | 5q35.3 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000283074 |
| UniProt ID | A0A1W2PRJ4 |
| OMIM ID | None |
| HGNC ID | HGNC:44295 |
| Aliases | TAF11L9, TAF11-like 9 |
Description
TAF11L9 is a protein-coding gene located on chromosome 5q35.3. It is a member of the TAF11 family, which encodes TATA-box binding protein (TBP)-associated factors that are components of the transcription factor IID (TFIID) complex. The exact function of TAF11L9 is not fully characterized, but it is predicted to be involved in transcriptional regulation. It is expressed in various tissues, with notable expression in the testis and some cancer cell lines.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential involvement in transcriptional dysregulation; specific mechanism not established. | Expression data from cancer cell lines (e.g., COSMIC) show altered expression, but no direct disease association is curated in ClinVar or OMIM. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.0 | Not detected (GTEx) - Note: Data may be limited; expression is generally low across tissues. |
| Thyroid | 0.0 | Not detected (GTEx) |
| Adipose | 0.0 | Not detected (GTEx) |
| Brain | 0.0 | Not detected (GTEx) |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.0 | Not detected in RNA-seq (depmap) - expression is very low or absent. |
| K562 | 0.0 | Not detected in RNA-seq (depmap) |
| MCF7 | 0.0 | Not detected in RNA-seq (depmap) |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants in ClinVar or COSMIC for TAF11L9. | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available; no loss-of-function mutations have been reported.
Gain of Function (GOF)
No data available; no gain-of-function mutations have been reported.
Dominant Negative (DN)
No data available; no dominant-negative mutations have been reported.
View complete mutation data：
Gene Ontology (GO)
| • Molecular Function: DNA binding (predicted) | • Biological Process: regulation of transcription by RNA polymerase II (predicted) |
| • Cellular Component: nucleus (predicted) |
Pathways
• No specific pathways are curated for TAF11L9 in major databases.
Protein Summary
The TAF11L9 protein is predicted to be a small protein (approximately 100 amino acids) with a domain similar to the TAF11 family. It likely interacts with TBP and other TAFs to form the TFIID complex, but its precise role is unknown. Due to its low expression and lack of functional studies, it may be a pseudogene or have a highly specialized function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAF11L9 Knockout HEK293 Cell Line | EDJ-KQ14821 | Human | 112488745 | Details Get a Quote |
| TAF11L9 Knockout A-549 Cell Line | EDJ-KQ46482 | Human | 112488745 | Details Get a Quote |
| TAF11L9 Knockout HCT 116 Cell Line | EDJ-KQ46483 | Human | 112488745 | Details Get a Quote |
| TAF11L9 Knockout HeLa Cell Line | EDJ-KQ46484 | Human | 112488745 | Details Get a Quote |
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