TAF11L7 Gene - TATA-Box Binding Protein Associated Factor 11 Like 7
A ribosomal protein gene with potential roles in cancer and development
Gene Information Card
| Symbol | TAF11L7 |
|---|---|
| Full Name | TATA-box binding protein associated factor 11 like 7 |
| Gene Type | protein coding |
| Chromosomal Location | 5q35.3 |
| NCBI Gene ID | 100129917 ncbi.nlm.nih.gov/gene/100129917 |
| Ensembl ID | ENSG00000278194 |
| UniProt ID | A0A0A0MRZ3 |
| OMIM ID | Not available |
| HGNC ID | HGNC:44277 |
| Aliases | TAF11-like 7, ribosomal protein S30-like |
Description
TAF11L7 is a protein-coding gene located on chromosome 5q35.3. It encodes a protein that shares sequence similarity with TAF11, a TATA-box binding protein associated factor, and also with ribosomal protein S30. The gene is part of a family of TAF11-like genes, but its exact function is not fully characterized. It is expressed in various tissues and may play a role in cellular processes such as transcription and translation, and has been implicated in certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential involvement in tumorigenesis; altered expression observed in some cancers | COSMIC, literature |
| Developmental disorders | Not established; requires further investigation | No direct evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | Low expression |
| Brain | Not available | Low expression |
| Liver | Not available | Low expression |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | Not available | Detected in some studies |
| HEK293 | Not available | Detected in some studies |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No specific variants reported | Not applicable | Not available | Not characterized |
Mutation functional classification
Loss of Function (LOF)
Not characterized; no known pathogenic loss-of-function variants reported.
Gain of Function (GOF)
Not characterized; no known gain-of-function variants reported.
Dominant Negative (DN)
Not characterized; no evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • Molecular function: protein binding (inferred from sequence similarity) | • Biological process: transcription regulation (inferred from sequence similarity) |
| • Cellular component: nucleus (inferred from sequence similarity) |
Protein Summary
The TAF11L7 protein is a small protein of approximately 60 amino acids, containing a zinc finger-like domain and a region homologous to ribosomal protein S30. It is predicted to localize to the nucleus and may be involved in transcriptional regulation or ribosome biogenesis. However, its precise function remains unknown, and no experimental characterization has been published.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAF11L7 Knockout HEK293 Cell Line | EDJ-KQ15598 | Human | 112488736 | Details Get a Quote |
| TAF11L7 Knockout A-549 Cell Line | EDJ-KQ46476 | Human | 112488736 | Details Get a Quote |
| TAF11L7 Knockout HCT 116 Cell Line | EDJ-KQ46477 | Human | 112488736 | Details Get a Quote |
| TAF11L7 Knockout HeLa Cell Line | EDJ-KQ46478 | Human | 112488736 | Details Get a Quote |
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