TAF11L5: TATA-Box Binding Protein Associated Factor 11 Like 5
A testis-specific TAF11-like protein with potential roles in spermatogenesis and transcriptional regulation.
Gene Information Card
| Symbol | TAF11L5 |
|---|---|
| Full Name | TATA-box binding protein associated factor 11 like 5 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q35.3 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000203883 |
| UniProt ID | A6NHL2 |
| OMIM ID | Not assigned |
| HGNC ID | HGNC:37216 |
| Aliases | TAF11L, TAF11-like |
Description
TAF11L5 is a protein-coding gene that encodes a member of the TAF11-like family. It is predominantly expressed in the testis and is thought to play a role in spermatogenesis by participating in transcription initiation complexes. The protein shares homology with TAF11, a component of the TFIID complex, but its specific functions remain under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Male infertility (spermatogenic failure) | Potential disruption of testis-specific transcription | Limited; inferred from expression pattern and homology |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Other tissues | <1.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Testicular germ cells | Not available | Predicted high expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants in major databases | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Protein Summary
The TAF11L5 protein is a 211-amino acid polypeptide with a conserved TAF11 domain. It is predicted to localize to the nucleus and may function as a transcription factor associated with the TFIID complex. Its testis-restricted expression suggests a specialized role in germ cell gene regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAF11L5 Knockout HEK293 Cell Line | EDJ-KQ15595 | Human | 646066 | Details Get a Quote |
| TAF11L5 Knockout A-549 Cell Line | EDJ-KQ46471 | Human | 646066 | Details Get a Quote |
| TAF11L5 Knockout HCT 116 Cell Line | EDJ-KQ46472 | Human | 646066 | Details Get a Quote |
| TAF11L5 Knockout HeLa Cell Line | EDJ-KQ46473 | Human | 646066 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
