TAF11L4 Gene - TATA-Box Binding Protein Associated Factor 11 Like 4
A testis-specific TAF11-like protein with potential roles in spermatogenesis and transcriptional regulation
Gene Information Card
| Symbol | TAF11L4 |
|---|---|
| Full Name | TATA-box binding protein associated factor 11 like 4 |
| Gene Type | protein coding |
| Chromosomal Location | 5q35.3 |
| NCBI Gene ID | 441951 ncbi.nlm.nih.gov/gene/441951 |
| Ensembl ID | ENSG00000205571 |
| UniProt ID | A6NKF1 |
| OMIM ID | Not available |
| HGNC ID | HGNC:33732 |
| Aliases | TAF11L4, TAF11-like 4, FLJ46257 |
Description
TAF11L4 (TATA-box binding protein associated factor 11 like 4) is a protein-coding gene located on chromosome 5q35.3. It encodes a protein that shares sequence similarity with TAF11, a subunit of the TFIID complex involved in RNA polymerase II transcription initiation. TAF11L4 is predominantly expressed in the testis, suggesting a specialized role in spermatogenesis. The protein contains a histone-fold domain, which is characteristic of TAF family members, and may participate in protein-protein interactions within transcriptional complexes. However, its exact function remains to be fully characterized.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease association | Not established | No direct evidence from OMIM or ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | High (RNA-seq data from GTEx, as reported by NCBI) |
| Other tissues | Not available | Low or not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No specific cell line data | Not available | No curated data from Human Protein Atlas |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | Not available | Not available | Not available |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • nucleus (GO:0005634) |
| • transcription initiation (GO:0006352) |
Pathways
• RNA polymerase II transcription initiation (inferred from TAF11 similarity)
Protein Summary
The TAF11L4 protein (UniProt A6NKF1) is 211 amino acids long and contains a histone-fold domain, a common feature of TAF proteins. It is predicted to localize to the nucleus and may interact with other transcription factors. Its testis-specific expression suggests a role in male germ cell development, possibly as a tissue-specific variant of TAF11 in the TFIID complex. However, experimental validation is lacking.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAF11L4 Knockout HEK293 Cell Line | EDJ-KQ14811 | Human | 391746 | Details Get a Quote |
| TAF11L4 Knockout A-549 Cell Line | EDJ-KQ46468 | Human | 391746 | Details Get a Quote |
| TAF11L4 Knockout HCT 116 Cell Line | EDJ-KQ46469 | Human | 391746 | Details Get a Quote |
| TAF11L4 Knockout HeLa Cell Line | EDJ-KQ46470 | Human | 391746 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
