TAF11L3 Gene - TATA-Box Binding Protein Associated Factor 11 Like 3
A testis-specific TAF11-like protein with potential roles in spermatogenesis and transcriptional regulation.
Gene Information Card
| Symbol | TAF11L3 |
|---|---|
| Full Name | TATA-box binding protein associated factor 11 like 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 5p15.1 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000214113 |
| UniProt ID | A6NKF1 |
| OMIM ID | Not available |
| HGNC ID | HGNC:37236 |
| Aliases | TAF11L3, TAF11-like 3, MGC:163194 |
Description
TAF11L3 (TATA-box binding protein associated factor 11 like 3) is a protein-coding gene located on chromosome 5p15.1. It encodes a protein that shares sequence similarity with TAF11, a subunit of the TFIID and TFTC complexes involved in RNA polymerase II transcription initiation. TAF11L3 is predominantly expressed in the testis, suggesting a specialized role in spermatogenesis. The protein contains a histone-fold domain, which is characteristic of TAF subunits and may mediate protein-protein interactions within transcriptional complexes. However, its exact function remains to be fully characterized.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No curated disease associations found in ClinVar or OMIM. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | High expression reported in testis (RNA-seq data from GTEx and Human Protein Atlas). |
| Other tissues | Not available | Low or no expression in other tissues. |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No cell line data | Not available | No specific cell line expression data available. |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | Not available | Not available | No pathogenic or common variants reported in ClinVar or COSMIC. |
Mutation functional classification
Loss of Function (LOF)
No evidence of loss-of-function mutations or their effects.
Gain of Function (GOF)
No evidence of gain-of-function mutations.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • Molecular function: protein binding (inferred from sequence similarity) | • Biological process: transcription initiation (inferred from sequence similarity) |
| • Cellular component: nucleus (inferred from sequence similarity) |
Pathways
• No specific pathways curated for TAF11L3. It may participate in TFIID-dependent transcription initiation by analogy to TAF11.
Protein Summary
The TAF11L3 protein (UniProt A6NKF1) is 211 amino acids long and contains a histone-fold domain, which is typical of TAF subunits. It is predicted to localize to the nucleus and may interact with other TAFs to form transcription complexes. Its testis-specific expression suggests a role in regulating genes involved in spermatogenesis. However, experimental validation of its function is lacking.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAF11L3 Knockout HEK293 Cell Line | EDJ-KQ15593 | Human | 646103 | Details Get a Quote |
| TAF11L3 Knockout A-549 Cell Line | EDJ-KQ46465 | Human | 646103 | Details Get a Quote |
| TAF11L3 Knockout HCT 116 Cell Line | EDJ-KQ46466 | Human | 646103 | Details Get a Quote |
| TAF11L3 Knockout HeLa Cell Line | EDJ-KQ46467 | Human | 646103 | Details Get a Quote |
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