TAF11L14 Gene: Structure, Function, and Clinical Relevance
A comprehensive overview of TAF11L14, a TAF11-like ribosomal RNA gene, including genomic context, expression, and disease associations.
Gene Information Card
| Symbol | TAF11L14 |
|---|---|
| Full Name | TAF11-like 14 (pseudogene) |
| Gene Type | Pseudogene (ribosomal RNA-related) |
| Chromosomal Location | Chromosome 5 (5q31.3) |
| NCBI Gene ID | 100287596 ncbi.nlm.nih.gov/gene/100287596 |
| Ensembl ID | ENSG00000234093 |
| UniProt ID | Not available (pseudogene) |
| OMIM ID | Not assigned |
| HGNC ID | HGNC:44277 |
| Aliases | TAF11L14, TAF11-like 14, RNA5SP? (if applicable) |
Description
TAF11L14 is a pseudogene located on chromosome 5q31.3, predicted to be transcribed but not translated into a functional protein. It shares sequence similarity with TAF11, a TATA-box binding protein-associated factor, but lacks a complete open reading frame. Its biological role, if any, remains largely uncharacterized, and it is not associated with any known disease phenotype.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease association | Not applicable | No curated disease links in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Not available | N/A | No expression data in GTEx or Human Protein Atlas for this pseudogene |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Not available | N/A | No cell line expression data reported |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | N/A | N/A | No pathogenic or benign variants reported in ClinVar or COSMIC |
Mutation functional classification
Loss of Function (LOF)
Not applicable; pseudogene with no known functional protein product.
Gain of Function (GOF)
Not applicable; no evidence of functional protein expression.
Dominant Negative (DN)
Not applicable; no functional protein to exert dominant-negative effects.
View complete mutation data：
Protein Summary
TAF11L14 is a pseudogene and does not encode a functional protein. It is not listed in UniProt, and no protein product has been identified. Its sequence similarity to TAF11 suggests a possible evolutionary origin, but it lacks the necessary coding elements for translation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAF11L14 Knockout HEK293 Cell Line | EDJ-KQ14827 | Human | 112488740 | Details Get a Quote |
| TAF11L14 Knockout A-549 Cell Line | EDJ-KQ46496 | Human | 112488740 | Details Get a Quote |
| TAF11L14 Knockout HCT 116 Cell Line | EDJ-KQ46498 | Human | 112488740 | Details Get a Quote |
| TAF11L14 Knockout HeLa Cell Line | EDJ-KQ46499 | Human | 112488740 | Details Get a Quote |
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