TAF11L12: TATA-Box Binding Protein Associated Factor 11 Like 12
A pseudogene-derived lncRNA with potential regulatory roles in gene expression
Gene Information Card
| Symbol | TAF11L12 |
|---|---|
| Full Name | TATA-box binding protein associated factor 11 like 12 |
| Gene Type | pseudogene (lncRNA) |
| Chromosomal Location | 5q35.3 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000235155 |
| UniProt ID | Not available (non-coding) |
| OMIM ID | Not available |
| HGNC ID | HGNC:37242 |
| Aliases | TAF11-like 12, TAF11L12 |
Description
TAF11L12 is a pseudogene derived from the TAF11 gene, located on chromosome 5q35.3. It is transcribed into a long non-coding RNA (lncRNA) but is not translated into a functional protein. The gene is part of the TAF11-like family, which includes multiple pseudogenes across the genome. Although its exact function is not fully characterized, pseudogene-derived lncRNAs can regulate their parental genes or other genes through mechanisms such as microRNA sponging or chromatin remodeling. TAF11L12 is expressed at low levels in various tissues, and its dysregulation has been implicated in certain cancers, though evidence is limited.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential dysregulation of lncRNA expression; may act as a competing endogenous RNA (ceRNA) or regulate TAF11 expression | Limited evidence from expression studies; no direct clinical association established |
| Not associated with specific Mendelian disorders | No known pathogenic variants; pseudogene with no protein product | No OMIM or ClinVar entries |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.4 | Low |
| Thyroid | 0.3 | Low |
| Adipose tissue | 0.2 | Low |
| Other tissues | 0.1-0.2 | Very low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 (leukemia) | 0.5 | Low expression |
| HeLa (cervical cancer) | 0.3 | Low expression |
| A549 (lung cancer) | 0.2 | Low expression |
| GM12878 (lymphoblastoid) | 0.1 | Very low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No known pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not applicable; pseudogene with no protein product
Gain of Function (GOF)
Not applicable; no functional protein
Dominant Negative (DN)
Not applicable
View complete mutation data：
Protein Summary
TAF11L12 does not encode a protein. It is a pseudogene that produces a long non-coding RNA. The RNA transcript may have regulatory roles, but no protein product is synthesized. Therefore, no protein structure or function is available.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAF11L12 Knockout HEK293 Cell Line | EDJ-KQ15604 | Human | 112488739 | Details Get a Quote |
| TAF11L12 Knockout A-549 Cell Line | EDJ-KQ46490 | Human | 112488739 | Details Get a Quote |
| TAF11L12 Knockout HCT 116 Cell Line | EDJ-KQ46491 | Human | 112488739 | Details Get a Quote |
| TAF11L12 Knockout HeLa Cell Line | EDJ-KQ46492 | Human | 112488739 | Details Get a Quote |
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