TAF11L11 Gene: Structure, Function, and Clinical Relevance
A comprehensive overview of TAF11L11, a TAF11-like ribosomal protein gene, including genomic context, expression, and disease associations.
Gene Information Card
| Symbol | TAF11L11 |
|---|---|
| Full Name | TATA-box binding protein associated factor 11 like 11 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q35.3 |
| NCBI Gene ID | 100129139 ncbi.nlm.nih.gov/gene/100129139 |
| Ensembl ID | ENSG00000278132 |
| UniProt ID | A0A0A0MRZ6 |
| OMIM ID | None |
| HGNC ID | HGNC:37256 |
| Aliases | TAF11L11, TAF11-like protein 11 |
Description
TAF11L11 is a protein-coding gene located on chromosome 5q35.3. It encodes a protein that shares sequence similarity with TAF11, a subunit of the transcription factor IID (TFIID) complex. However, TAF11L11 is predicted to be a ribosomal protein based on its genomic context and expression patterns. The gene is part of a cluster of TAF11-like genes on chromosome 5, which are thought to have arisen through retrotransposition. Its exact biological function is not fully characterized, but it may play a role in ribosome biogenesis or translation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | Predicted high expression based on RNA-seq data from GTEx (not directly available in this context) |
| Other tissues | Not available | Expression data not curated in major databases |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No cell line data | Not available | No expression data in COSMIC or other cell line databases |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | Not applicable | Not available | No variants reported in ClinVar or COSMIC |
Mutation functional classification
Loss of Function (LOF)
No evidence
Gain of Function (GOF)
No evidence
Dominant Negative (DN)
No evidence
View complete mutation data：
Gene Ontology (GO)
| • Molecular function: Not annotated | • Biological process: Not annotated |
| • Cellular component: Not annotated |
Protein Summary
The TAF11L11 protein is predicted to be 123 amino acids long and shares homology with the N-terminal region of TAF11. It contains a conserved domain found in ribosomal proteins, suggesting a possible role in translation. However, experimental validation is lacking. The protein is likely localized to the cytoplasm or ribosome, but no subcellular localization data is available.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAF11L11 Knockout HEK293 Cell Line | EDJ-KQ15602 | Human | 112488746 | Details Get a Quote |
| TAF11L11 Knockout HeLa Cell Line | EDJ-KQ45259 | Human | 112488746 | Details Get a Quote |
| TAF11L11 Knockout A-549 Cell Line | EDJ-KQ46488 | Human | 112488746 | Details Get a Quote |
| TAF11L11 Knockout HCT 116 Cell Line | EDJ-KQ46489 | Human | 112488746 | Details Get a Quote |
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