TAF11L10 Gene: TAF11 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 11 Like 10
A ribosomal protein gene with potential roles in cancer and development, located on chromosome 5p15.2.
Gene Information Card
| Symbol | TAF11L10 |
|---|---|
| Full Name | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 11 like 10 |
| Gene Type | protein-coding |
| Chromosomal Location | 5p15.2 |
| NCBI Gene ID | 100129139 ncbi.nlm.nih.gov/gene/100129139 |
| Ensembl ID | ENSG00000214113 |
| UniProt ID | A6NKF9 |
| OMIM ID | Not available |
| HGNC ID | HGNC:37232 |
| Aliases | RPL13AP20, TAF11L10 |
Description
TAF11L10 is a protein-coding gene located on chromosome 5p15.2. It is a member of the TAF11-like family and is also annotated as a ribosomal protein L13a pseudogene (RPL13AP20). The gene is expressed in various tissues and has been implicated in cancer and developmental processes. Its exact function is not fully characterized, but it may play a role in transcriptional regulation or ribosome biogenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer | Potential involvement in tumorigenesis; altered expression observed in some cancers. | COSMIC, literature |
| Developmental disorders | Possible role in development; further studies needed. | Inferred from gene family |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | Low expression |
| Brain | Not available | Low expression |
| Liver | Not available | Low expression |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | Not available | Detected in some studies |
| K562 | Not available | Detected in some studies |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | SNV | Not available | Potential impact on protein function; not validated |
| c.2T>C | SNV | Not available | Potential impact on protein function; not validated |
Mutation functional classification
Loss of Function (LOF)
Not established; no functional studies available.
Gain of Function (GOF)
Not established; no functional studies available.
Dominant Negative (DN)
Not established; no functional studies available.
View complete mutation data：
Gene Ontology (GO)
| • Molecular function: Not available | • Biological process: Not available |
| • Cellular component: Not available |
Pathways
• Not available
Protein Summary
The TAF11L10 protein is predicted to be a small, basic protein with similarity to TAF11 and ribosomal protein L13a. Its exact function is unknown, but it may be involved in transcriptional regulation or ribosome assembly. No experimental characterization is available.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAF11L10 Knockout HEK293 Cell Line | EDJ-KQ15601 | Human | 112488738 | Details Get a Quote |
| TAF11L10 Knockout A-549 Cell Line | EDJ-KQ46485 | Human | 112488738 | Details Get a Quote |
| TAF11L10 Knockout HCT 116 Cell Line | EDJ-KQ46486 | Human | 112488738 | Details Get a Quote |
| TAF11L10 Knockout HeLa Cell Line | EDJ-KQ46487 | Human | 112488738 | Details Get a Quote |
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