TADA2B
Transcriptional Adaptor 2B
Gene Information Card
| Symbol | TADA2B |
|---|---|
| Full Name | Transcriptional Adaptor 2B |
| Gene Type | Protein coding |
| Chromosomal Location | 4p16.1 |
| NCBI Gene ID | 93624 ncbi.nlm.nih.gov/gene/93624 |
| Ensembl ID | ENSG00000138668 |
| UniProt ID | Q5VWG9 |
| OMIM ID | 614713 |
| HGNC ID | 30790 |
| Aliases | ADA2B, hADA2b, FLJ11273 |
Description
TADA2B (Transcriptional Adaptor 2B) is a protein-coding gene located on chromosome 4p16.1. It encodes a component of the SAGA (Spt-Ada-Gcn5-acetyltransferase) and ATAC (Ada-Two-A-containing) histone acetyltransferase complexes, which regulate transcription by modifying chromatin structure. TADA2B is involved in histone acetylation, transcriptional activation, and cellular differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations reported in ClinVar | Not applicable | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 6.2 | Low |
| Lung | 4.8 | Low |
| Liver | 3.1 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 8.3 | Embryonic kidney cells |
| HeLa | 6.7 | Cervical cancer cells |
| K562 | 5.1 | Leukemia cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | Not reported | Unknown effect |
| c.100C>T | Nonsense | Not reported | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations may lead to truncated protein and loss of SAGA complex function.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • histone acetyltransferase activity | • transcription coactivator activity |
| • chromatin binding | • nucleus |
| • SAGA complex | • ATAC complex |
| • positive regulation of transcription by RNA polymerase II |
Pathways
• Chromatin modifying enzymes
• Transcriptional regulation by the SAGA complex
Protein Summary
TADA2B is a 443-amino acid protein that serves as an adaptor subunit within the SAGA and ATAC histone acetyltransferase complexes. It facilitates the interaction between the catalytic subunit GCN5 and other complex components, promoting histone H3 acetylation and transcriptional activation. TADA2B is ubiquitously expressed with higher levels in testis and plays roles in development and cellular differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TADA2B Knockout HEK293 Cell Line | EDJ-KQ11246 | Human | 93624 | Details Get a Quote |
| TADA2B Knockout HCT 116 Cell Line | EDJ-KQ38018 | Human | 93624 | Details Get a Quote |
| TADA2B Knockout A-549 Cell Line | EDJ-KQ39341 | Human | 93624 | Details Get a Quote |
| TADA2B Knockout HeLa Cell Line | EDJ-KQ39342 | Human | 93624 | Details Get a Quote |
